MolNFT v1 · #31152 · protein

Human muscle aldolase

2ALD · Fructose-bisphosphate aldolase: “Human muscle aldolase”. X-ray diffraction, 2 pockets (best druggability 0.74). MolNFT v1 #31152 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2ALD
Type: protein
Length: 363 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Fructose-bisphosphate aldolase
EC: 4.1.2.13
UniProt: P04075
Pockets: 2 · best druggability 0.74

Structure

x-ray diffraction · 1 distinct chain · 45% helix, 14% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Fructose-bisphosphate aldolase (EC 4.1.2.13)	protein	363	45% helix, 14% strand	P04075

Pockets

2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	488	0.74	0.83	48	empty
2	177	0.58	0.82	30	empty

Compared structures

2ALD · Human muscle aldolase · the same entry in another collection · chain A against A, TM-score 1.00
P04075 · AlphaFold monomer V2.0 prediction for fructose-bisphosphate aldolase a (P04075) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P04075
Elsewhere: RCSB PDB 2ALD · PDBe 2ALD · UniProt P04075

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