Research workbench
Crystal structure of the TCERG1 FF4-6 tandem repeat domain
Analyse Crystal structure of the TCERG1 FF4-6 tandem repeat domain in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4FQG
- Type
- protein
- Length
- 375 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Transcription elongation regulator 1
- UniProt
- O14776
- Ligands
- NI, CL
- Pockets
- 2 · best druggability 0.43
Structure
x-ray diffraction · 2 distinct chains · 72% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Transcription elongation regulator 1 | protein | 186 | 73% helix, 0% strand | O14776 |
| B | Transcription elongation regulator 1 | protein | 189 | 72% helix, 0% strand | O14776 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 159 | 0.43 | 0.74 | 22 | empty |
| 2 | 74 | 0.29 | 0.72 | 16 | empty |
Interfaces
1 interface between chains.
- A–B · 205 Ų buried · 2 hydrogen bonds · protein-protein
Compared structures
- 4FQG · Crystal structure of the TCERG1 FF4-6 tandem repeat domain · the same entry in another collection · chain A against A, TM-score 1.00
- O14776 · AlphaFold monomer V2.0 prediction for transcription elongation regulator 1 (O14776) · a predicted model of the same protein · chain A against A, TM-score 0.91
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O14776
- Elsewhere: RCSB PDB 4FQG · PDBe 4FQG · UniProt O14776
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