Research workbench
Structural and biochemical characterization of human adenylosuccinate lyase (adsl) and the R303C adsl deficiency associated mutation
Analyse Structural and biochemical characterization of human adenylosuccinate lyase… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4FLC
- Type
- protein
- Length
- 1,839 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Adenylosuccinate lyase
- EC
- 4.3.2.2
- UniProt
- P30566
- Pockets
- 20 · best druggability 0.83
Structure
x-ray diffraction · 4 distinct chains · 67% helix, 4% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Adenylosuccinate lyase (EC 4.3.2.2) | protein | 460 | 66% helix, 4% strand | P30566 |
| B | Adenylosuccinate lyase (EC 4.3.2.2) | protein | 464 | 67% helix, 4% strand | P30566 |
| C | Adenylosuccinate lyase (EC 4.3.2.2) | protein | 453 | 67% helix, 4% strand | P30566 |
| D | Adenylosuccinate lyase (EC 4.3.2.2) | protein | 462 | 68% helix, 4% strand | P30566 |
Pockets
20 pockets found on a 1 Å grid, 14 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 359 | 0.83 | 0.93 | 35 | empty |
| 2 | 552 | 0.82 | 0.88 | 50 | empty |
| 3 | 788 | 0.81 | 0.84 | 86 | empty |
| 4 | 1084 | 0.80 | 0.82 | 108 | empty |
| 5 | 960 | 0.80 | 0.81 | 86 | empty |
Interfaces
6 interfaces between chains.
- C–D · 3811 Ų buried · 81 hydrogen bonds · protein-protein
- A–B · 3743 Ų buried · 65 hydrogen bonds · protein-protein
- A–D · 2516 Ų buried · 41 hydrogen bonds · protein-protein
- B–C · 2415 Ų buried · 42 hydrogen bonds · protein-protein
- B–D · 1937 Ų buried · 20 hydrogen bonds · protein-protein
Compared structures
- 4FLC · Structural and Biochemical Characterization of Human Adenylosuccinate Lyase (ADSL) and… · the same entry in another collection · chain D against D, TM-score 1.00
- P30566 · AlphaFold monomer V2.0 prediction for adenylosuccinate lyase (P30566) · a predicted model of the same protein · chain C against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P30566
- Elsewhere: RCSB PDB 4FLC · PDBe 4FLC · UniProt P30566
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