UniProt P30566
Adenylosuccinate lyase (P30566)
Adenylosuccinate lyase (UniProt P30566), EC 4.3.2.2: 8 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 150 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P30566
- Protein
- Adenylosuccinate lyase
- EC
- 4.3.2.2
- Experimental structures
- 8
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 150 · 9 records with a druggable one
Structures
9 records of P30566 in the MolNFT archive: 8 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2J91 | Crystal structure of Human Adenylosuccinate Lyase in complex with AMP | x-ray diffraction | A, B, C, D | AMP, CL | 15 (best 0.85) |
| 2J91 | Crystal structure of human adenylosuccinate lyase in complex with AMP | x-ray diffraction | A, B, C, D | AMP, CL | 15 (best 0.85) |
| 2VD6 | Human adenylosuccinate lyase in complex with its substrate N6-(1,2- Dicarboxyethyl)-AMP, and its… | x-ray diffraction | A, B, C, D | AMP, FUM, CL, 2SA | 20 (best 0.86) |
| 2VD6 | Human adenylosuccinate lyase in complex with its substrate N6-(1,2-dicarboxyethyl)-AMP, and its… | x-ray diffraction | A, B, C, D | AMP, FUM, CL, 2SA | 20 (best 0.86) |
| 4FFX | Structural and Biochemical Characterization of Human Adenylosuccinate Lyase (ADSL) and the R303C… | x-ray diffraction | A, B, C, D | — | 18 (best 0.84) |
| 4FFX | Structural and biochemical characterization of human adenylosuccinate lyase (adsl) and the R303C… | x-ray diffraction | A, B, C, D | — | 18 (best 0.84) |
| 4FLC | Structural and Biochemical Characterization of Human Adenylosuccinate Lyase (ADSL) and the R303C… | x-ray diffraction | A, B, C, D | — | 20 (best 0.83) |
| 4FLC | Structural and biochemical characterization of human adenylosuccinate lyase (adsl) and the R303C… | x-ray diffraction | A, B, C, D | — | 20 (best 0.83) |
| P30566 | AlphaFold monomer V2.0 prediction for adenylosuccinate lyase (P30566) | predicted | A | — | 4 (best 0.67) |
Ligands
Experiment against prediction
- 2J91 chain A against the predicted model P30566: TM-score 1.00, RMSD 0.62 Å
- 2J91 chain A against the predicted model P30566: TM-score 1.00, RMSD 0.62 Å
- 2VD6 chain C against the predicted model P30566: TM-score 0.99, RMSD 0.62 Å
- 2VD6 chain C against the predicted model P30566: TM-score 0.99, RMSD 0.62 Å
- 2J91 chain C against the predicted model P30566: TM-score 0.99, RMSD 0.64 Å
- 2J91 chain C against the predicted model P30566: TM-score 0.99, RMSD 0.64 Å
- 2VD6 chain B against the predicted model P30566: TM-score 0.99, RMSD 0.64 Å
- 2VD6 chain B against the predicted model P30566: TM-score 0.99, RMSD 0.64 Å
- 2VD6 chain D against the predicted model P30566: TM-score 0.99, RMSD 0.69 Å
- 2VD6 chain D against the predicted model P30566: TM-score 0.99, RMSD 0.69 Å
Elsewhere
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