Research workbench
Crystal structure of beta-ketoacyl-acp synthase III + degraded form of acetyl-CoA
Analyse Crystal structure of beta-ketoacyl-acp synthase III + degraded form of… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1HNH
- Type
- protein
- Length
- 317 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Beta-ketoacyl-acyl carrier protein synthase III
- EC
- 2.3.1.41
- UniProt
- P0A6R0
- Ligands
- COA
- Pockets
- 1 · best druggability 0.65
Structure
x-ray diffraction · 1 distinct chain · 39% helix, 26% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Beta-ketoacyl-acyl carrier protein synthase III (EC 2.3.1.41) | protein | 317 | 39% helix, 26% strand | P0A6R0 |
Ligands and binding sites
- COA · Coenzyme A · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 163 | 0.65 | 0.86 | 27 | empty |
Modifications
Observed in the structure: 9 modified (engineered, acetylation).
Compared structures
- 1HNH · Crystal structure of beta-ketoacyl-acp synthase III + degraded form of acetyl-CoA · the same entry in another collection · chain A against A, TM-score 1.00
- P0A6R0 · AlphaFold monomer V2.0 prediction for 3-oxoacyl-[acyl-carrier- protein] synthase 3… · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P0A6R0
- Elsewhere: RCSB PDB 1HNH · PDBe 1HNH · UniProt P0A6R0
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