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Catalytic domain of human PAK4

Analyse Catalytic domain of human PAK4 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4FIJ
Type: protein
Length: 292 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: SERINE/THREONINE-protein kinase pak 4
EC: 2.7.11.1
UniProt: O96013
Pockets: 3 · best druggability 0.54

Structure

x-ray diffraction · 1 distinct chain · 41% helix, 18% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	SERINE/THREONINE-protein kinase pak 4 (EC 2.7.11.1)	protein	292	41% helix, 18% strand	O96013

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	155	0.54	0.81	28	empty
2	51	0.33	0.78	15	empty
3	52	0.32	0.77	17	empty

Modifications

Observed in the structure: 1 modified (phosphorylation).

Compared structures

4FIJ · Catalytic domain of human PAK4 · the same entry in another collection · chain A against A, TM-score 1.00
O96013 · AlphaFold monomer V2.0 prediction for SERINE/THREONINE-protein kinase pak 4 (O96013) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O96013
Elsewhere: RCSB PDB 4FIJ · PDBe 4FIJ · UniProt O96013

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