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The structure of deoxy and oxy hemerythrin at 2.0 ångströms resolution

Analyse The structure of deoxy and oxy hemerythrin at 2.0 ångströms resolution in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1HMO
Type: protein
Length: 452 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Hemerythrin
UniProt: P02246
Ligands: ACE, FEO, OXY
Pockets: 5 · best druggability 0.53

Structure

x-ray diffraction · 1 distinct chain · 72% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C, D	Hemerythrin	protein	113	72% helix, 0% strand	P02246

Ligands and binding sites

ACE · Acetyl group · ligand · 4 copies · chains A, B, C, D
FEO · Mu-oxo-diiron · ligand · 4 copies · chains A, B, C, D
OXY · Oxygen molecule · ion · 4 copies · chains A, B, C, D

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	290	0.53	0.75	28	empty
2	65	0.35	0.77	11	empty
3	61	0.32	0.76	15	empty
4	52	0.30	0.76	14	empty
5	53	0.26	0.73	11	empty

Interfaces

3 interfaces between chains.

C–D · 932 Å² buried · 19 hydrogen bonds · protein-protein
A–D · 204 Å² buried · 1 hydrogen bond · protein-protein
A–B · 169 Å² buried · 0 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 covalent (covalent ligand).

Compared structures

1HMO · The structure of deoxy and oxy hemerythrin at 2.0 ångströms resolution · the same entry in another collection · chain A against A, TM-score 1.00
P02246 · AlphaFold monomer V2.0 prediction for hemerythrin (P02246) · a predicted model of the same protein · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P02246
Elsewhere: RCSB PDB 1HMO · PDBe 1HMO · UniProt P02246

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