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Ligand · FEO

FEO · Mu-oxo-diiron

FEO, Mu-oxo-diiron (Fe2 O, 127.7 g/mol), in the MolNFT structures on GenesisL1: bound in 16 records (11 PDB entries). Every binding site with its residues within 4.5 Å, the residues it binds most and the ligands found with it.

Component
FEO
Formula
Fe2 O
Class
ligand
Structures
16
PDB entries
11

Binding sites

FEO in 16 structures; the first of them:

  • 5CI0 · Ribonucleotide reductase Y122 3,5-F2Y variant · FEO A401 · binds ASP84, TRP111, GLU115, HIS118, GLU204, PHE208, GLU238, HIS241
  • 5CI2 · Ribonucleotide reductase Y122 2,3,6-F3Y variant · FEO A401 · binds ASP84, TRP111, GLU115, HIS118, GLU204, PHE208, ILE234, GLU238 and 1 more
  • 5CI3 · Ribonucleotide reductase Y122 2,3,5-F3Y variant · FEO A401 · binds ASP84, TRP111, GLU115, HIS118, GLU204, PHE208, ILE234, GLU238 and 1 more
  • 5KIL · CmlA beta-hydroxylase E377D mutant · FEO A601 · binds HIS258, HIS305, HIS307, ASP309, HIS310, ASP377, ASP403
  • 5LMC · Oxidized flavodiiron core of Escherichia coli flavorubredoxin, including the Fe-4SG atoms… · FEO A501 · binds HIS79, GLU81, ASP83, HIS84, HIS147, ASP166, SER226, HIS227
  • 5V8S · Flavo di-iron protein H90D mutant from Thermotoga maritima · FEO A401 · binds HIS85, GLU87, ASP89, ASP90, HIS151, ASP168, TYR197, HIS228
  • 6ZLF · Aerobic crystal structure of F420H2-Oxidase from Methanothermococcus thermolithotrophicus… · FEO A502 · binds TYR25, HIS84, GLU86, ASP88, HIS89, HIS152, ASP171, SER233 and 1 more
  • 7MDI · Structure of the Neisseria gonorrhoeae ribonucleotide reductase in the inactive state · FEO E501 · binds ASP85, TRP112, GLU116, HIS119, GLU239, HIS242
  • 7R2O · Crystal structure of a flavodiiron protein S262Y mutant in the oxidized state from… · FEO A502 · binds HIS79, GLU81, ASP83, HIS84, HIS147, ASP166, TYR194, SER226 and 1 more
  • 9DB2 · Class Ia ribonucleotide reductase with mechanism-based inhibitor N3CDP · FEO C401 · binds ASP84, TRP111, GLU115, HIS118, GLU204, PHE208, ILE234, GLU238 and 1 more
  • 5KIL · Cmla beta-hydroxylase E377D mutant · FEO A601 · binds HIS258, HIS305, HIS307, ASP309, HIS310, ASP377, ASP403
  • 5LMC · Oxidized flavodiiron core of escherichia COLI flavorubredoxin, including the fe-4SG atoms… · FEO A501 · binds HIS79, GLU81, ASP83, HIS84, HIS147, ASP166, HIS227
  • 5V8S · Flavo di-iron protein H90D mutant from thermotoga maritima · FEO A401 · binds HIS85, GLU87, ASP89, ASP90, HIS151, ASP168, HIS228
  • 6W4X · Holocomplex of E. COLI class ia ribonucleotide reductase with GDP and ttp · FEO C501 · binds ASP84, GLU115, HIS118, FY3122, GLU204, GLU238, HIS241
  • 6ZLF · Aerobic crystal structure of F420H2-oxidase from methanothermococcus thermolithotrophicus… · FEO A502 · binds TYR25, HIS84, GLU86, ASP88, HIS89, HIS152, ASP171, HIS234
  • 7MDI · Structure of the neisseria gonorrhoeae ribonucleotide reductase in the inactive state · FEO E501 · binds ASP85, TRP112, GLU116, HIS119, GLU239, HIS242

Residues it binds most

HIS 41, ASP 41, GLU 39, TRP 14, TYR 12, SER 11, PHE 5, ILE 3, FY3 1 (residue and the binding sites it lines).

Found with

  • FMN · Flavin mononucleotide
  • MG · Magnesium ion
  • CL · Chloride ion
  • ACT · Acetate ion
  • DTP · 2'-deoxyadenosine 5'-triphosphate
  • SO4 · Sulfate ion
  • GOL · Glycerol
  • CDP · Cytidine-5'-diphosphate
  • FE · Fe (III) ion
  • K · Potassium ion
  • KR · Krypton
  • PO4 · Phosphate ion

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