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Crystal structure of calcium-bound alpha-1 giardin

Analyse Crystal structure of calcium-bound alpha-1 giardin in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4EVH
Type: protein
Length: 294 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Giardin subunit alpha-1
UniProt: P17063
Ligands: CA
Pockets: 2 · best druggability 0.32

Structure

x-ray diffraction · 1 distinct chain · 77% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Giardin subunit alpha-1	protein	294	77% helix, 0% strand	P17063

Ligands and binding sites

CA · Calcium ion · metal · 2 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	53	0.32	0.77	16	empty
2	53	0.29	0.75	15	empty

Compared structures

4EVH · Crystal structure of calcium-bound alpha-1 giardin · the same entry in another collection · chain A against A, TM-score 1.00
P17063 · AlphaFold monomer V2.0 prediction for giardin subunit alpha-1 (P17063) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P17063
Elsewhere: RCSB PDB 4EVH · PDBe 4EVH · UniProt P17063

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