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Crystal structure of the C-terminal domain of human XPB/ERCC-3 excision repair protein at 1.80 a

Analyse Crystal structure of the C-terminal domain of human XPB/ERCC-3 excision repair… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4ERN
Type: protein
Length: 229 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Tfiih basal transcription factor complex helicase xpb subunit
EC: 3.6.4.12
UniProt: P19447
Pockets: 3 · best druggability 0.42

Structure

x-ray diffraction · 1 distinct chain · 46% helix, 16% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Tfiih basal transcription factor complex helicase xpb subunit (EC 3.6.4.12)	protein	229	46% helix, 16% strand	P19447

Pockets

3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	57	0.42	0.83	18	empty
2	53	0.33	0.78	12	empty
3	70	0.32	0.74	15	empty

Compared structures

4ERN · Crystal structure of the C-terminal domain of human XPB/ERCC-3 excision repair protein at… · the same entry in another collection · chain A against A, TM-score 1.00
P19447 · AlphaFold monomer V2.0 prediction for general transcription and DNA repair factor iih… · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P19447
Elsewhere: RCSB PDB 4ERN · PDBe 4ERN · UniProt P19447

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