Research workbench
Crystal structure of yldv 14L il-18 binding protein in complex with human il-18
Analyse Crystal structure of yldv 14L il-18 binding protein in complex with human il-18 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4EEE
- Type
- protein
- Length
- 518 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- 14L protein; Interleukin-18
- UniProt
- Q9DHU8, Q14116
- Pockets
- 6 · best druggability 0.60
Structure
x-ray diffraction · 4 distinct chains · 7% helix, 48% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | 14L protein | protein | 115 | 11% helix, 43% strand | Q9DHU8 |
| B | Interleukin-18 | protein | 147 | 4% helix, 52% strand | Q14116 |
| C | 14L protein | protein | 115 | 11% helix, 43% strand | Q9DHU8 |
| D | Interleukin-18 | protein | 141 | 4% helix, 52% strand | Q14116 |
Pockets
6 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 112 | 0.60 | 0.86 | 22 | empty |
| 2 | 91 | 0.58 | 0.86 | 20 | empty |
| 3 | 267 | 0.54 | 0.76 | 24 | empty |
| 4 | 222 | 0.50 | 0.76 | 25 | empty |
| 5 | 131 | 0.44 | 0.76 | 19 | empty |
Interfaces
3 interfaces between chains.
- A–B · 993 Ų buried · 8 hydrogen bonds · protein-protein
- C–D · 993 Ų buried · 7 hydrogen bonds · protein-protein
- A–C · 883 Ų buried · 17 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 5 disulfide (disulfide).
Compared structures
- 4EEE · Crystal Structure of YLDV 14L IL-18 Binding Protein in Complex with Human IL-18 · the same entry in another collection · chain A against A, TM-score 1.00
- Q14116 · AlphaFold monomer V2.0 prediction for interleukin-18 (Q14116) · a predicted model of the same protein · chain D against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9DHU8
- Every structure of UniProt Q14116
- Elsewhere: RCSB PDB 4EEE · PDBe 4EEE · UniProt Q9DHU8 · UniProt Q14116
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.