UniProt Q14116
Interleukin-18 (Q14116)
Interleukin-18 (UniProt Q14116), EC 2.5.1.18: 32 experimental structures and 1 predicted model on GenesisL1, 25 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q14116
- Protein
- Interleukin-18
- EC
- 2.5.1.18
- Experimental structures
- 32
- Predicted models
- 1
- Pockets
- 25 · 3 records with a druggable one
Structures
33 records of Q14116 in the MolNFT archive: 32 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1J0S | Solution structure of the human interleukin-18 | solution nmr | A | — | — |
| 1J0S | Solution structure of the human interleukin-18 | solution nmr | A | — | — |
| 2VXT | Crystal structure of human IL-18 complexed to murine reference antibody 125-2H Fab | x-ray diffraction | I | — | — |
| 2VXT | Crystal structure of human il-18 complexed to murine reference antibody 125-2H Fab | x-ray diffraction | I | — | — |
| 3F62 | Crystal Structure of Human IL-18 in complex with Ectromelia virus IL-18 Binding Protein | x-ray diffraction | B | — | — |
| 3F62 | Crystal structure of human il-18 in complex with ectromelia virus il- 18 binding protein | x-ray diffraction | B | — | — |
| 3WO2 | Crystal structure of human interleukin-18 | x-ray diffraction | A, B, C, D | — | — |
| 3WO2 | Crystal structure of human interleukin-18 | x-ray diffraction | A, B, C, D | — | — |
| 3WO3 | Crystal structure of IL-18 in complex with IL-18 receptor alpha | x-ray diffraction | A, C, E, G, I, K | — | — |
| 3WO3 | Crystal structure of il-18 in complex with il-18 receptor alpha | x-ray diffraction | A, C, E, G, I, K | — | — |
| 3WO4 | Crystal structure of the IL-18 signaling ternary complex | x-ray diffraction | A | — | — |
| 3WO4 | Crystal structure of the il-18 signaling ternary complex | x-ray diffraction | A | — | — |
| 4EEE | Crystal Structure of YLDV 14L IL-18 Binding Protein in Complex with Human IL-18 | x-ray diffraction | B, D | — | — |
| 4EEE | Crystal structure of yldv 14L il-18 binding protein in complex with human il-18 | x-ray diffraction | B, D | — | — |
| 4EKX | Crystal Structure of YLDV 14L IL-18 Binding Protein in Complex with Human IL-18 | x-ray diffraction | B, D | — | — |
| 4EKX | Crystal structure of yldv 14L il-18 binding protein in complex with human il-18 | x-ray diffraction | B, D | — | — |
| 4HJJ | Structure Reveals Function of the Dual Variable Domain Immunoglobulin (DVD-Ig) Molecule | x-ray diffraction | A | — | — |
| 4HJJ | Structure reveals function of the dual variable domain immunoglobulin (dvd-ig) molecule | x-ray diffraction | A | — | — |
| 4R6U | IL-18 receptor complex | x-ray diffraction | B, D | — | — |
| 4R6U | Il-18 receptor complex | x-ray diffraction | B, D | — | — |
| 4XFS | Structure of IL-18 SER Mutant I | x-ray diffraction | A, B | — | — |
| 4XFS | Structure of il-18 ser mutant I | x-ray diffraction | A, B | — | — |
| 4XFT | Structure of IL-18 SER Mutant III | x-ray diffraction | A, B | — | — |
| 4XFT | Structure of il-18 ser mutant III | x-ray diffraction | A, B | — | — |
| 4XFU | Structure of IL-18 SER Mutant V | x-ray diffraction | A, B | — | — |
| 4XFU | Structure of il-18 ser mutant V | x-ray diffraction | A, B | — | — |
| 7AL7 | The Crystal Structure of Human IL-18 in Complex With Human IL-18 Binding Protein | x-ray diffraction | B | — | 1 (best 0.34) |
| 7AL7 | The crystal structure of human il-18 in complex with human il-18 binding protein | x-ray diffraction | B | — | — |
| 8J6K | Crystal structure of pro-interleukin-18 and caspase-4 complex | x-ray diffraction | B | — | 4 (best 0.51) |
| 8SPB | Caspase-4/Pro-IL-18 complex | electron microscopy | C, c | — | 13 (best 0.55) |
| 8SV1 | Caspase-1 complex with interleukin-18 | electron microscopy | C, c | — | 7 (best 0.75) |
| 8URV | Solution NMR structure of pro-IL-18 | solution nmr | A | — | — |
| Q14116 | AlphaFold monomer V2.0 prediction for interleukin-18 (Q14116) | predicted | A | — | — |
Experiment against prediction
- 3WO3 chain A against the predicted model Q14116: TM-score 0.99, RMSD 0.53 Å
- 3WO3 chain A against the predicted model Q14116: TM-score 0.99, RMSD 0.53 Å
- 3WO3 chain E against the predicted model Q14116: TM-score 0.98, RMSD 0.61 Å
- 3WO3 chain E against the predicted model Q14116: TM-score 0.98, RMSD 0.61 Å
- 3WO2 chain B against the predicted model Q14116: TM-score 0.98, RMSD 0.66 Å
- 3WO2 chain B against the predicted model Q14116: TM-score 0.98, RMSD 0.66 Å
- 4R6U chain B against the predicted model Q14116: TM-score 0.98, RMSD 0.69 Å
- 4R6U chain B against the predicted model Q14116: TM-score 0.98, RMSD 0.69 Å
- 3WO2 chain A against the predicted model Q14116: TM-score 0.98, RMSD 0.87 Å
- 3WO2 chain A against the predicted model Q14116: TM-score 0.98, RMSD 0.87 Å
Elsewhere
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