MolNFT v1 · #109882 · protein
Structure of il-18 ser mutant V
4XFU · Interleukin-18: “Structure of il-18 ser mutant V”. X-ray diffraction, 2 pockets (best druggability 0.56). MolNFT v1 #109882 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 4XFU
- Type
- protein
- Length
- 299 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Interleukin-18
- UniProt
- Q14116
- Pockets
- 2 · best druggability 0.56
Structure
x-ray diffraction · 2 distinct chains · 3% helix, 47% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Interleukin-18 | protein | 149 | 4% helix, 49% strand | Q14116 |
| B | Interleukin-18 | protein | 150 | 2% helix, 45% strand | Q14116 |
Pockets
2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 235 | 0.56 | 0.78 | 31 | empty |
| 2 | 307 | 0.56 | 0.76 | 35 | empty |
Interfaces
1 interface between chains.
- A–B · 389 Ų buried · 1 hydrogen bond · protein-protein
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q14116
- Elsewhere: RCSB PDB 4XFU · PDBe 4XFU · UniProt Q14116
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.