MolNFT v1 · #173000 · protein
The crystal structure of human il-18 in complex with human il-18 binding protein
7AL7 · Interleukin-18-binding protein: “The crystal structure of human il-18 in complex with human il-18 binding protein”. X-ray diffraction, 1 ligand (NAG), 1 pocket (best druggability 0.34). MolNFT v1 #173000 on GenesisL1: 3D structure…
- PDB
- 7AL7
- Type
- protein
- Length
- 265 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Interleukin-18-binding protein; Glutathione S-transferase class-mu 26 kda isozyme…
- EC
- 2.5.1.18
- UniProt
- O95998, Q14116
- Ligands
- NAG
- Pockets
- 1 · best druggability 0.34
Structure
x-ray diffraction · 2 distinct chains · 9% helix, 49% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Interleukin-18-binding protein | protein | 108 | 11% helix, 48% strand | O95998 |
| B | Glutathione S-transferase class-mu 26 kda isozyme, interleukin-18 (EC 2.5.1.18) | protein | 157 | 8% helix, 50% strand | Q14116 |
Ligands and binding sites
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 3 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 57 | 0.34 | 0.77 | 16 | empty |
Interfaces
1 interface between chains.
- A–B · 930 Ų buried · 9 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 3 glycan, 2 disulfide, 2 modified (N-glycosylation, disulfide, cyclization, oxidation).
Compared structures
- 7AL7 · The Crystal Structure of Human IL-18 in Complex With Human IL-18 Binding Protein · the same entry in another collection · chain A against A, TM-score 1.00
- O95998 · AlphaFold monomer V2.0 prediction for interleukin-18-binding protein (O95998) · a predicted model of the same protein · chain A against A, TM-score 0.97
- Q14116 · AlphaFold monomer V2.0 prediction for interleukin-18 (Q14116) · a predicted model of the same protein · chain B against A, TM-score 0.95
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O95998
- Every structure of UniProt Q14116
- Elsewhere: RCSB PDB 7AL7 · PDBe 7AL7 · UniProt O95998 · UniProt Q14116
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