Research workbench
Crystal structure of streptococcal beta-galactosidase in complex with galactose
Analyse Crystal structure of streptococcal beta-galactosidase in complex with galactose in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4E8C
- Type
- protein
- Length
- 1,183 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Glycosyl hydrolase, family 35
- EC
- 3.2.1.23
- UniProt
- Q97T90
- Ligands
- GAL
- Pockets
- 12 · best druggability 0.73
Structure
x-ray diffraction · 2 distinct chains · 26% helix, 33% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Glycosyl hydrolase, family 35 (EC 3.2.1.23) | protein | 594 | 26% helix, 33% strand | Q97T90 |
| B | Glycosyl hydrolase, family 35 (EC 3.2.1.23) | protein | 589 | 27% helix, 33% strand | Q97T90 |
Ligands and binding sites
- GAL · beta-D-galactopyranose · sugar · 2 copies · chains A, B
- GOL · Glycerol · additive · 15 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
12 pockets found on a 1 Å grid, 8 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 781 | 0.73 | 0.79 | 70 | empty |
| 2 | 505 | 0.70 | 0.80 | 38 | GOL |
| 3 | 434 | 0.65 | 0.78 | 38 | empty |
| 4 | 407 | 0.64 | 0.77 | 36 | GOL |
| 5 | 247 | 0.61 | 0.81 | 40 | GAL |
Interfaces
1 interface between chains.
- A–B · 1549 Ų buried · 19 hydrogen bonds · protein-protein
Compared structures
- 4E8C · Crystal structure of streptococcal beta-galactosidase in complex with galactose · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q97T90
- Elsewhere: RCSB PDB 4E8C · PDBe 4E8C · UniProt Q97T90
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.