Research workbench
Structure of human MAD1 C-terminal domain reveals its involvement in kinetochore targeting
Analyse Structure of human MAD1 C-terminal domain reveals its involvement in… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4DZO
- Type
- protein
- Length
- 237 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Mitotic spindle assembly checkpoint protein MAD1
- UniProt
- Q9Y6D9
- Pockets
- 2 · best druggability 0.28
Structure
x-ray diffraction · 2 distinct chains · 57% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Mitotic spindle assembly checkpoint protein MAD1 | protein | 117 | 57% helix, 18% strand | Q9Y6D9 |
| B | Mitotic spindle assembly checkpoint protein MAD1 | protein | 120 | 58% helix, 16% strand | Q9Y6D9 |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 52 | 0.28 | 0.74 | 15 | empty |
| 2 | 57 | 0.27 | 0.73 | 19 | empty |
Interfaces
1 interface between chains.
- A–B · 2218 Ų buried · 7 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 modified (engineered).
Compared structures
- 4DZO · Structure of Human Mad1 C-terminal Domain Reveals Its Involvement in Kinetochore Targeting · the same entry in another collection · chain A against A, TM-score 1.00
- Q9Y6D9 · AlphaFold monomer V2.0 prediction for mitotic spindle assembly checkpoint protein MAD1… · a predicted model of the same protein · chain A against A, TM-score 0.88
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9Y6D9
- Elsewhere: RCSB PDB 4DZO · PDBe 4DZO · UniProt Q9Y6D9
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