UniProt Q9Y6D9
Mitotic spindle assembly checkpoint protein MAD1 (Q9Y6D9)
Mitotic spindle assembly checkpoint protein MAD1 (UniProt Q9Y6D9): 10 experimental structures and 1 predicted model on GenesisL1, 28 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q9Y6D9
- Protein
- Mitotic spindle assembly checkpoint protein MAD1
- Experimental structures
- 10
- Predicted models
- 1
- Pockets
- 28 · 2 records with a druggable one
Structures
11 records of Q9Y6D9 in the MolNFT archive: 10 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1GO4 | Crystal structure of Mad1-Mad2 reveals a conserved Mad2 binding motif in Mad1 and Cdc20. | x-ray diffraction | E, F, G, H | — | 15 (best 0.77) |
| 1GO4 | Crystal structure of MAD1-MAD2 reveals a conserved MAD2 binding motif in MAD1 and CDC20. | x-ray diffraction | E, F, G, H | — | — |
| 4DZO | Structure of Human Mad1 C-terminal Domain Reveals Its Involvement in Kinetochore Targeting | x-ray diffraction | A, B | — | — |
| 4DZO | Structure of human MAD1 C-terminal domain reveals its involvement in kinetochore targeting | x-ray diffraction | A, B | — | — |
| 7B1F | Orthorhombic P212121 Structure of Human Mad1 C-terminal Domain in Complex with Phosphorylated Bub1… | x-ray diffraction | B, A | — | 2 (best 0.39) |
| 7B1F | Orthorhombic P212121 structure of human MAD1 C-terminal domain in complex with phosphorylated BUB1… | x-ray diffraction | B, A | — | — |
| 7B1H | Monoclinic P21 Structure of Human Mad1 C-terminal Domain in Complex with Phosphorylated Bub1 CD1… | x-ray diffraction | B, A, E, F | — | 8 (best 0.69) |
| 7B1H | Monoclinic P21 structure of human MAD1 C-terminal domain in complex with phosphorylated BUB1 CD1… | x-ray diffraction | B, A, E, F | — | — |
| 7B1J | Orthorhombic P21212 Structure of Human Mad1 C-terminal Domain in Complex with Phosphorylated Bub1… | x-ray diffraction | B, A | — | 2 (best 0.35) |
| 7B1J | Orthorhombic P21212 structure of human MAD1 C-terminal domain in complex with phosphorylated BUB1… | x-ray diffraction | B, A | — | — |
| Q9Y6D9 | AlphaFold monomer V2.0 prediction for mitotic spindle assembly checkpoint protein MAD1 (Q9Y6D9) | predicted | A | — | 1 (best 0.29) |
Experiment against prediction
- 7B1F chain A against the predicted model Q9Y6D9: TM-score 0.88, RMSD 1.75 Å
- 7B1F chain A against the predicted model Q9Y6D9: TM-score 0.88, RMSD 1.75 Å
- 7B1F chain B against the predicted model Q9Y6D9: TM-score 0.88, RMSD 1.76 Å
- 7B1F chain B against the predicted model Q9Y6D9: TM-score 0.88, RMSD 1.76 Å
- 4DZO chain A against the predicted model Q9Y6D9: TM-score 0.88, RMSD 1.89 Å
- 4DZO chain A against the predicted model Q9Y6D9: TM-score 0.88, RMSD 1.89 Å
- 7B1J chain B against the predicted model Q9Y6D9: TM-score 0.87, RMSD 1.92 Å
- 7B1J chain B against the predicted model Q9Y6D9: TM-score 0.87, RMSD 1.92 Å
- 7B1H chain B against the predicted model Q9Y6D9: TM-score 0.86, RMSD 2.07 Å
- 7B1H chain B against the predicted model Q9Y6D9: TM-score 0.86, RMSD 2.07 Å
Elsewhere
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