Research workbench
Crystal structure of the ternary complex between S100A10, an annexin A2 N-terminal peptide and an ahnak peptide
Analyse Crystal structure of the ternary complex between S100A10, an annexin A2… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4DRW
- Type
- protein
- Length
- 434 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Protein S100-A10/ANNEXIN A2 chimeric protein; Neuroblast differentiation-associated…
- UniProt
- P60903, P07355, Q09666
- Pockets
- 4 · best druggability 0.77
Structure
x-ray diffraction · 3 distinct chains · 54% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C | Protein S100-A10/ANNEXIN A2 chimeric protein | protein | 103 | 57% helix, 0% strand | P60903, P07355 |
| B, D | Protein S100-A10/ANNEXIN A2 chimeric protein | protein | 104 | 57% helix, 0% strand | P60903, P07355 |
| E, F | Neuroblast differentiation-associated protein ahnak | protein | 10 | 0% helix, 0% strand | Q09666 |
Pockets
4 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 963 | 0.77 | 0.79 | 88 | empty |
| 2 | 100 | 0.62 | 0.88 | 17 | empty |
| 3 | 100 | 0.54 | 0.83 | 20 | empty |
| 4 | 68 | 0.43 | 0.81 | 16 | empty |
Interfaces
11 interfaces between chains.
- A–B · 1996 Ų buried · 22 hydrogen bonds · protein-protein
- C–D · 1960 Ų buried · 24 hydrogen bonds · protein-protein
- C–F · 448 Ų buried · 0 hydrogen bonds · protein-protein
- A–E · 379 Ų buried · 1 hydrogen bond · protein-protein
- D–F · 349 Ų buried · 3 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 4DRW · Crystal Structure of the Ternary Complex between S100A10, an Annexin A2 N-terminal… · the same entry in another collection · chain F against F, TM-score 1.00
- P60903 · AlphaFold monomer V2.0 prediction for protein S100-A10 (P60903) · a predicted model of the same protein · chain A against A, TM-score 0.83
- P07355 · AlphaFold monomer V2.0 prediction for annexin A2 (P07355) · a predicted model of the same protein · chain A against A, TM-score 0.36
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P60903
- Every structure of UniProt P07355
- Every structure of UniProt Q09666
- Elsewhere: RCSB PDB 4DRW · PDBe 4DRW · UniProt P60903 · UniProt P07355 · UniProt Q09666
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