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Crystal structure of human interleukin-34

Analyse Crystal structure of human interleukin-34 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4DKC
Type: protein
Length: 321 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Interleukin-34
UniProt: Q6ZMJ4
Ligands: NAG, BMA

Structure

x-ray diffraction · 2 distinct chains · 63% helix, 4% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Interleukin-34	protein	161	62% helix, 4% strand	Q6ZMJ4
B	Interleukin-34	protein	160	64% helix, 4% strand	Q6ZMJ4

Ligands and binding sites

NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 4 copies · chains A, B
BMA · beta-D-mannopyranose · sugar · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Interfaces

1 interface between chains.

A–B · 653 Å² buried · 2 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 disulfide, 2 glycan (disulfide, N-glycosylation).

Compared structures

4DKC · Crystal Structure of Human Interleukin-34 · the same entry in another collection · chain B against B, TM-score 1.00
Q6ZMJ4 · AlphaFold monomer V2.0 prediction for interleukin-34 (Q6ZMJ4) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q6ZMJ4
Elsewhere: RCSB PDB 4DKC · PDBe 4DKC · UniProt Q6ZMJ4

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