Research workbench

Myosin VI D179Y (md) pre-powerstroke state

Analyse Myosin VI D179Y (md) pre-powerstroke state in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4DBR
Type: protein
Length: 754 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Myosin-VI
UniProt: F1RQI7
Ligands: ADP, MG, VO4
Pockets: 6 · best druggability 0.75

Structure

x-ray diffraction · 1 distinct chain · 49% helix, 16% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Myosin-VI	protein	754	49% helix, 16% strand	F1RQI7

Ligands and binding sites

ADP · Adenosine-5'-diphosphate · ligand · chains A
MG · Magnesium ion · metal · chains A
VO4 · Vanadate ion · ion · chains A
EDO · 1,2-ethanediol · additive · 8 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

6 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	843	0.75	0.79	77	EDO
2	405	0.73	0.84	53	ADP, MG, VO4
3	444	0.68	0.79	46	EDO
4	171	0.64	0.85	33	EDO
5	66	0.36	0.77	16	empty

Compared structures

4DBR · Myosin VI D179Y (MD) pre-powerstroke state · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt F1RQI7
Elsewhere: RCSB PDB 4DBR · PDBe 4DBR · UniProt F1RQI7

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