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Crystal structure of avian fak ferm domain FAK31-405 at 3.2A
Analyse Crystal structure of avian fak ferm domain FAK31-405 at 3.2A in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4CYE
- Type
- protein
- Length
- 664 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Focal adhesion kinase 1
- EC
- 2.7.10.2
- UniProt
- Q00944
- Pockets
- 5 · best druggability 0.77
Structure
x-ray diffraction · 2 distinct chains · 42% helix, 24% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Focal adhesion kinase 1 (EC 2.7.10.2) | protein | 330 | 42% helix, 23% strand | Q00944 |
| B | Focal adhesion kinase 1 (EC 2.7.10.2) | protein | 334 | 42% helix, 25% strand | Q00944 |
Pockets
5 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 920 | 0.77 | 0.80 | 86 | empty |
| 2 | 532 | 0.67 | 0.78 | 64 | empty |
| 3 | 553 | 0.66 | 0.77 | 60 | empty |
| 4 | 58 | 0.44 | 0.83 | 13 | empty |
| 5 | 67 | 0.40 | 0.80 | 15 | empty |
Interfaces
1 interface between chains.
- A–B · 412 Ų buried · 11 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q00944
- Elsewhere: RCSB PDB 4CYE · PDBe 4CYE · UniProt Q00944
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