Research workbench
Crystal structure of the KANSL1-WDR5-KANSL2 complex.
Analyse Crystal structure of the KANSL1-WDR5-KANSL2 complex. in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4CY2
- Type
- protein
- Length
- 325 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Wd repeat-containing protein 5; KAT8 regulatory nsl complex subunit 2; KAT8 regulatory…
- UniProt
- P61964, Q9H9L4, Q7Z3B3
- Pockets
- 1 · best druggability 0.74
Structure
x-ray diffraction · 3 distinct chains · 1% helix, 48% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Wd repeat-containing protein 5 | protein | 304 | 0% helix, 52% strand | P61964 |
| C | KAT8 regulatory nsl complex subunit 2 | protein | 9 | 0% helix, 0% strand | Q9H9L4 |
| D | KAT8 regulatory nsl complex subunit 1 | protein | 12 | 25% helix, 0% strand | Q7Z3B3 |
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 533 | 0.74 | 0.82 | 46 | empty |
Interfaces
2 interfaces between chains.
- A–D · 734 Ų buried · 15 hydrogen bonds · protein-protein
- A–C · 441 Ų buried · 9 hydrogen bonds · protein-protein
Compared structures
- 4CY2 · Crystal structure of the KANSL1-WDR5-KANSL2 complex. · the same entry in another collection · chain D against D, TM-score 1.00
- Q9H9L4 · AlphaFold monomer V2.0 prediction for KAT8 regulatory nsl complex subunit 2 (Q9H9L4) · a predicted model of the same protein · chain C against A, TM-score 0.38
- Q7Z3B3 · AlphaFold monomer V2.0 prediction for KAT8 regulatory nsl complex subunit 1 (Q7Z3B3) · a predicted model of the same protein · chain D against A, TM-score 0.34
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P61964
- Every structure of UniProt Q9H9L4
- Every structure of UniProt Q7Z3B3
- Elsewhere: RCSB PDB 4CY2 · PDBe 4CY2 · UniProt P61964 · UniProt Q9H9L4 · UniProt Q7Z3B3
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