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Crystal structure of the KANSL1-WDR5 complex.

Analyse Crystal structure of the KANSL1-WDR5 complex. in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4CY1
Type: protein
Length: 632 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Wd repeat-containing protein 5; KAT8 regulatory nsl complex subunit 1
UniProt: P61964, Q7Z3B3
Pockets: 3 · best druggability 0.73

Structure

x-ray diffraction · 3 distinct chains · 0% helix, 50% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Wd repeat-containing protein 5	protein	303	0% helix, 51% strand	P61964
B	Wd repeat-containing protein 5	protein	301	0% helix, 51% strand	P61964
C, D	KAT8 regulatory nsl complex subunit 1	protein	14	21% helix, 0% strand	Q7Z3B3

Ligands and binding sites

GOL · Glycerol · additive · 3 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	464	0.73	0.82	45	empty
2	466	0.73	0.82	45	empty
3	51	0.26	0.73	18	empty

Interfaces

3 interfaces between chains.

B–C · 747 Å² buried · 13 hydrogen bonds · protein-protein
A–D · 723 Å² buried · 15 hydrogen bonds · protein-protein
A–B · 533 Å² buried · 7 hydrogen bonds · protein-protein

Compared structures

4CY1 · Crystal structure of the KANSL1-WDR5 complex. · the same entry in another collection · chain C against C, TM-score 1.00
Q7Z3B3 · AlphaFold monomer V2.0 prediction for KAT8 regulatory nsl complex subunit 1 (Q7Z3B3) · a predicted model of the same protein · chain C against A, TM-score 0.34

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P61964
Every structure of UniProt Q7Z3B3
Elsewhere: RCSB PDB 4CY1 · PDBe 4CY1 · UniProt P61964 · UniProt Q7Z3B3

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