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Crystal structure of cofactor-free urate oxidase in complex with the 5-peroxo derivative of 9-metyl uric acid (X-ray dose, 2.5 kgy)

Analyse Crystal structure of cofactor-free urate oxidase in complex with the 5-peroxo… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4CW2
Type: protein
Length: 301 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Uricase
EC: 1.7.3.3
UniProt: Q00511
Ligands: XDS
Pockets: 2 · best druggability 0.56

Structure

x-ray diffraction · 1 distinct chain · 27% helix, 38% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Uricase (EC 1.7.3.3)	protein	301	27% helix, 38% strand	Q00511

Ligands and binding sites

XDS · (5S)-5-(dioxidanyl)-9-methyl-7H-purine-2,6,8-trione · ligand · chains A
MPD · (4S)-2-methyl-2,4-pentanediol · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	222	0.56	0.78	21	empty
2	199	0.49	0.76	24	XDS

Modifications

Observed in the structure: 1 modified (acetylation).

Compared structures

4CW2 · Crystal structure of cofactor-free urate oxidase in complex with the 5-peroxo derivative… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q00511
Elsewhere: RCSB PDB 4CW2 · PDBe 4CW2 · UniProt Q00511

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