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Human PDK1-pkczeta kinase chimera

Analyse Human PDK1-pkczeta kinase chimera in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4CT2
Type: protein
Length: 278 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: 3-phosphoinositide-dependent protein kinase 1
EC: 2.7.11.1
UniProt: O15530
Ligands: ATP, NA
Pockets: 3 · best druggability 0.60

Structure

x-ray diffraction · 1 distinct chain · 39% helix, 18% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	3-phosphoinositide-dependent protein kinase 1 (EC 2.7.11.1)	protein	278	39% helix, 18% strand	O15530

Ligands and binding sites

ATP · Adenosine-5'-triphosphate · ligand · chains A
NA · Sodium ion · metal · chains A
DTD · Dithiane diol · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	303	0.60	0.78	30	ATP
2	60	0.42	0.82	18	empty
3	56	0.26	0.73	19	empty

Modifications

Observed in the structure: 1 modified (phosphorylation).

Compared structures

4CT2 · Human PDK1-PKCzeta Kinase Chimera · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O15530
Elsewhere: RCSB PDB 4CT2 · PDBe 4CT2 · UniProt O15530

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