Research workbench
Crystal structure of mouse CRYPTOCHROME1 in complex with PERIOD2
Analyse Crystal structure of mouse CRYPTOCHROME1 in complex with PERIOD2 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4CT0
- Type
- protein
- Length
- 582 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Cryptochrome-1; Period circadian protein homolog 2
- UniProt
- P97784, O54943
- Ligands
- ZN, CL
- Pockets
- 7 · best druggability 0.68
Structure
x-ray diffraction · 2 distinct chains · 48% helix, 8% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Cryptochrome-1 | protein | 486 | 48% helix, 7% strand | P97784 |
| B | Period circadian protein homolog 2 | protein | 96 | 45% helix, 8% strand | O54943 |
Ligands and binding sites
- ZN · Zinc ion · metal · chains A, B
- CL · Chloride ion · ion · chains A
- P6G · Hexaethylene glycol · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
7 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 419 | 0.68 | 0.80 | 51 | empty |
| 2 | 194 | 0.66 | 0.85 | 39 | empty |
| 3 | 94 | 0.51 | 0.82 | 20 | empty |
| 4 | 76 | 0.45 | 0.81 | 18 | empty |
| 5 | 105 | 0.38 | 0.75 | 21 | empty |
Interfaces
1 interface between chains.
- A–B · 3319 Ų buried · 33 hydrogen bonds · protein-protein
Compared structures
- 4CT0 · Crystal Structure of Mouse Cryptochrome1 in Complex with Period2 · the same entry in another collection · chain A against A, TM-score 1.00
- P97784 · AlphaFold monomer V2.0 prediction for cryptochrome-1 (P97784) · a predicted model of the same protein · chain A against A, TM-score 0.98
- O54943 · AlphaFold monomer V2.0 prediction for period circadian protein homolog 2 (O54943) · a predicted model of the same protein · chain B against A, TM-score 0.44
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P97784
- Every structure of UniProt O54943
- Elsewhere: RCSB PDB 4CT0 · PDBe 4CT0 · UniProt P97784 · UniProt O54943
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