UniProt P97784
Cryptochrome-1 (P97784)
Cryptochrome-1 (UniProt P97784): 17 experimental structures and 1 predicted model on GenesisL1, 8 ligands bound, 20 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P97784
- Protein
- Cryptochrome-1
- Experimental structures
- 17
- Predicted models
- 1
- Ligands
- 8
- Pockets
- 20 · 2 records with a druggable one
Structures
18 records of P97784 in the MolNFT archive: 17 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4CT0 | Crystal Structure of Mouse Cryptochrome1 in Complex with Period2 | x-ray diffraction | A | — | — |
| 4CT0 | Crystal structure of mouse CRYPTOCHROME1 in complex with PERIOD2 | x-ray diffraction | A | — | — |
| 4K0R | Crystal structure of mouse Cryptochrome 1 | x-ray diffraction | A | — | — |
| 4K0R | Crystal structure of mouse cryptochrome 1 | x-ray diffraction | A | — | — |
| 5T5X | High resolution structure of mouse cryptochrome 1 | x-ray diffraction | A | CL | — |
| 6KX4 | Crystal structure of mouse cryptochrome 1 apo form | x-ray diffraction | A | — | — |
| 6KX5 | Crystal structure of mouse cryptochrome 1 in complex with KL044 compound | x-ray diffraction | A | DYR | — |
| 6KX6 | Crystal structure of mouse cryptochrome 1 in complex with KL101 compound | x-ray diffraction | A, B | DYU | — |
| 6KX7 | Crystal structure of mouse cryptochrome 1 in complex with TH301 compound | x-ray diffraction | A | DYX | — |
| 6LUE | Crystal structure of mouse Cryptochrome 1 in complex with compound KL201 | x-ray diffraction | A, B | EUL | 7 (best 0.75) |
| 6LUE | Crystal structure of mouse cryptochrome 1 in complex with compound KL201 | x-ray diffraction | A, B | EUL | — |
| 6OF7 | Crystal structure of the CRY1-PER2 complex | x-ray diffraction | A | — | — |
| 7D0M | Crystal structure of mouse CRY1 with bound cryoprotectant | — | — | — | |
| 7D19 | Crystal structure of mouse cryptochrome 1 in complex with compound TH129 | x-ray diffraction | A, B | GOC | — |
| 7D1C | Crystal structure of mouse cryptochrome 1 in complex with compound TH303 | x-ray diffraction | A | GOF | — |
| 7DLI | Crystal structure of mouse CRY1 in complex with KL001 compound | x-ray diffraction | A, B, C | H8X | 13 (best 0.83) |
| 7DLI | Crystal structure of mouse CRY1 in complex with KL001 compound | x-ray diffraction | A, B, C | H8X | — |
| P97784 | AlphaFold monomer V2.0 prediction for cryptochrome-1 (P97784) | predicted | A | — | — |
Ligands
- EUL · 2-bromanyl-N-(5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-yl)benzamide · in 2 records
- H8X · N-[(2R)-3-carbazol-9-yl-2-oxidanyl-propyl]-N-(furan-2-ylmethyl)methanesulfonamide · in 2 records
- CL · Chloride ion · in 1 record
- DYR · 2-carbazol-9-yl-N-(2-chloranyl-6-cyano-phenyl) ethanamide · in 1 record
- DYU · ~{N}-[2-(2,4-dimethylphenyl)-4,6-dihydrothieno[3,4-c]pyrazol-3-yl]-3,4-dimethyl-benzamide · in 1 record
- DYX · 1-(4-chlorophenyl)-N-[2-(4-methoxyphenyl)-5,5-bis(oxidanylidene)-4,6-dihydrothieno[3,4-c]pyrazol-3-yl]cyclopentane-1-carboxamide · in 1 record
- GOC · N-[2-(2,4-dimethylphenyl)-4,6-dihydrothieno[3,4-c]pyrazol-3-yl]-4-(phenylcarbonyl)benzamide · in 1 record
- GOF · N-[2-(4-methoxyphenyl)-5,5-bis(oxidanylidene)-4,6-dihydrothieno[3,4-c]pyrazol-3-yl]-4-(phenylcarbonyl) benzamide · in 1 record
Experiment against prediction
- 6LUE chain A against the predicted model P97784: TM-score 0.99, RMSD 0.65 Å
- 6LUE chain A against the predicted model P97784: TM-score 0.99, RMSD 0.65 Å
- 6KX6 chain B against the predicted model P97784: TM-score 0.99, RMSD 0.65 Å
- 6KX6 chain A against the predicted model P97784: TM-score 0.99, RMSD 0.66 Å
- 6KX4 chain A against the predicted model P97784: TM-score 0.99, RMSD 0.82 Å
- 6LUE chain B against the predicted model P97784: TM-score 0.99, RMSD 0.69 Å
- 6LUE chain B against the predicted model P97784: TM-score 0.99, RMSD 0.69 Å
- 6KX7 chain A against the predicted model P97784: TM-score 0.99, RMSD 0.83 Å
- 7DLI chain A against the predicted model P97784: TM-score 0.99, RMSD 0.89 Å
- 7DLI chain A against the predicted model P97784: TM-score 0.99, RMSD 0.89 Å
Elsewhere
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