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Crystal structure of the rod domain of alpha-actinin

Analyse Crystal structure of the rod domain of alpha-actinin in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1HCI
Type: protein
Length: 950 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Alpha-actinin 2
UniProt: P35609
Pockets: 14 · best druggability 0.61

Structure

x-ray diffraction · 1 distinct chain · 78% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Alpha-actinin 2	protein	475	78% helix, 0% strand	P35609

Pockets

14 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	402	0.61	0.76	48	empty
2	283	0.56	0.76	34	empty
3	228	0.54	0.77	29	empty
4	178	0.52	0.78	25	empty
5	163	0.50	0.78	24	empty

Interfaces

1 interface between chains.

A–B · 3456 Å² buried · 21 hydrogen bonds · protein-protein

Compared structures

1HCI · Crystal structure of the rod domain of alpha-actinin · the same entry in another collection · chain A against A, TM-score 1.00
P35609 · AlphaFold monomer V2.0 prediction for alpha-actinin-2 (P35609) · a predicted model of the same protein · chain B against A, TM-score 0.52

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P35609
Elsewhere: RCSB PDB 1HCI · PDBe 1HCI · UniProt P35609

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