Research workbench
The electron crystallography structure of the camp-bound potassium channel MLOK1
Analyse The electron crystallography structure of the camp-bound potassium channel MLOK1 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4CHV
- Type
- protein
- Length
- 1,372 residues
- Chains
- 4
- Method
- electron crystallography
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Cyclic nucleotide-gated potassium channel MLL3241
- UniProt
- Q98GN8
- Ligands
- K
- Pockets
- 20 · best druggability 0.84
Structure
electron crystallography · 1 distinct chain · 64% helix, 9% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D | Cyclic nucleotide-gated potassium channel MLL3241 | protein | 343 | 64% helix, 9% strand | Q98GN8 |
Ligands and binding sites
- K · Potassium ion · metal · 2 copies · chains A, B, C, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 991 | 0.84 | 0.85 | 102 | empty |
| 2 | 1000 | 0.80 | 0.81 | 105 | empty |
| 3 | 1111 | 0.78 | 0.79 | 114 | empty |
| 4 | 758 | 0.77 | 0.81 | 65 | empty |
| 5 | 845 | 0.76 | 0.80 | 79 | empty |
Interfaces
6 interfaces between chains.
- A–B · 2519 Ų buried · 33 hydrogen bonds · protein-protein
- B–C · 2504 Ų buried · 29 hydrogen bonds · protein-protein
- A–D · 2493 Ų buried · 30 hydrogen bonds · protein-protein
- C–D · 2470 Ų buried · 30 hydrogen bonds · protein-protein
- A–C · 167 Ų buried · 2 hydrogen bonds · protein-protein
Compared structures
- 4CHV · The electron crystallography structure of the cAMP-bound potassium channel MloK1 · the same entry in another collection · chain D against D, TM-score 1.00
- Q98GN8 · AlphaFold monomer V2.0 prediction for cyclic nucleotide-gated potassium channel MLL3241… · a predicted model of the same protein · chain D against A, TM-score 0.69
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q98GN8
- Elsewhere: RCSB PDB 4CHV · PDBe 4CHV · UniProt Q98GN8
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