Research workbench
Crystal structure of a human ANP32E-H2A.Z-H2B complex
Analyse Crystal structure of a human ANP32E-H2A.Z-H2B complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4CAY
- Type
- protein
- Length
- 201 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Histone H2A.Z; Histone H2B type 1-J; Acidic leucine-rich nuclear phosphoprotein 32 family…
- UniProt
- P0C0S5, P06899, Q9BTT0
- Pockets
- 1 · best druggability 0.31
Structure
x-ray diffraction · 3 distinct chains · 68% helix, 4% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Histone H2A.Z | protein | 86 | 73% helix, 3% strand | P0C0S5 |
| B | Histone H2B type 1-J | protein | 92 | 75% helix, 4% strand | P06899 |
| C | Acidic leucine-rich nuclear phosphoprotein 32 family member E | protein | 23 | 22% helix, 4% strand | Q9BTT0 |
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 54 | 0.31 | 0.76 | 15 | empty |
Interfaces
3 interfaces between chains.
- A–B · 2636 Ų buried · 24 hydrogen bonds · protein-protein
- B–C · 638 Ų buried · 9 hydrogen bonds · protein-protein
- A–C · 611 Ų buried · 10 hydrogen bonds · protein-protein
Compared structures
- 4CAY · Crystal structure of a human Anp32e-H2A.Z-H2B complex · the same entry in another collection · chain A against A, TM-score 1.00
- P0C0S5 · AlphaFold monomer V2.0 prediction for histone H2A.Z (P0C0S5) · a predicted model of the same protein · chain A against A, TM-score 0.91
- Q9BTT0 · AlphaFold monomer V2.0 prediction for acidic leucine-rich nuclear phosphoprotein 32… · a predicted model of the same protein · chain C against A, TM-score 0.23
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P0C0S5
- Every structure of UniProt P06899
- Every structure of UniProt Q9BTT0
- Elsewhere: RCSB PDB 4CAY · PDBe 4CAY · UniProt P0C0S5 · UniProt P06899 · UniProt Q9BTT0
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