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Mouse ZNRF3 ectodomain crystal form III
Analyse Mouse ZNRF3 ectodomain crystal form III in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4C8C
- Type
- protein
- Length
- 290 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- E3 ubiquitin-protein ligase ZNRF3
- EC
- 6.3.2.-
- UniProt
- Q5SSZ7
- Pockets
- 4 · best druggability 0.54
Structure
x-ray diffraction · 2 distinct chains · 22% helix, 38% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | E3 ubiquitin-protein ligase ZNRF3 (EC 6.3.2.-) | protein | 146 | 22% helix, 38% strand | Q5SSZ7 |
| B | E3 ubiquitin-protein ligase ZNRF3 (EC 6.3.2.-) | protein | 144 | 22% helix, 38% strand | Q5SSZ7 |
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 116 | 0.54 | 0.82 | 24 | empty |
| 2 | 79 | 0.46 | 0.82 | 16 | empty |
| 3 | 65 | 0.43 | 0.81 | 15 | empty |
| 4 | 102 | 0.37 | 0.75 | 17 | empty |
Interfaces
1 interface between chains.
- A–B · 1174 Ų buried · 26 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q5SSZ7
- Elsewhere: RCSB PDB 4C8C · PDBe 4C8C · UniProt Q5SSZ7
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