Research workbench
Crystal structure of wild-type RAB11 complexed to FIP2
Analyse Crystal structure of wild-type RAB11 complexed to FIP2 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4C4P
- Type
- protein
- Length
- 223 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- RAS-related protein rab-11A; RAB11 family-interacting protein 2
- UniProt
- P62491, Q7L804
- Ligands
- GNP, MG
- Pockets
- 2 · best druggability 0.48
Structure
x-ray diffraction · 2 distinct chains · 43% helix, 22% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | RAS-related protein rab-11A | protein | 167 | 32% helix, 29% strand | P62491 |
| B | RAB11 family-interacting protein 2 | protein | 56 | 77% helix, 4% strand | Q7L804 |
Ligands and binding sites
- GNP · Phosphoaminophosphonic acid-guanylate ester · ligand · chains A
- MG · Magnesium ion · metal · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 118 | 0.48 | 0.80 | 26 | GNP, MG |
| 2 | 92 | 0.41 | 0.78 | 13 | empty |
Interfaces
1 interface between chains.
- A–B · 626 Ų buried · 6 hydrogen bonds · protein-protein
Compared structures
- 4C4P · Crystal Structure of Wild-Type Rab11 Complexed to FIP2 · the same entry in another collection · chain A against A, TM-score 1.00
- P62491 · AlphaFold monomer V2.0 prediction for RAS-related protein rab-11A (P62491) · a predicted model of the same protein · chain A against A, TM-score 0.96
- Q7L804 · AlphaFold monomer V2.0 prediction for RAB11 family-interacting protein 2 (Q7L804) · a predicted model of the same protein · chain B against A, TM-score 0.87
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P62491
- Every structure of UniProt Q7L804
- Elsewhere: RCSB PDB 4C4P · PDBe 4C4P · UniProt P62491 · UniProt Q7L804
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