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Crystal structure of the titin M10-obscurin ig domain 1 complex

Analyse Crystal structure of the titin M10-obscurin ig domain 1 complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4C4K
Type: protein
Length: 191 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Obscurin; Titin
EC: 2.7.11.1
UniProt: Q5VST9, Q8WZ42
Pockets: 1 · best druggability 0.33

Structure

x-ray diffraction · 2 distinct chains · 5% helix, 61% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
O	Obscurin (EC 2.7.11.1)	protein	94	3% helix, 59% strand	Q5VST9
T	Titin (EC 2.7.11.1)	protein	97	6% helix, 63% strand	Q8WZ42

Ligands and binding sites

EDO · 1,2-ethanediol · additive · 12 copies · chains O, T

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	69	0.33	0.76	16	empty

Interfaces

1 interface between chains.

O–T · 824 Å² buried · 12 hydrogen bonds · protein-protein

Compared structures

4C4K · Crystal structure of the titin M10-Obscurin Ig domain 1 complex · the same entry in another collection · chain O against O, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q5VST9
Every structure of UniProt Q8WZ42
Elsewhere: RCSB PDB 4C4K · PDBe 4C4K · UniProt Q5VST9 · UniProt Q8WZ42

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