Research workbench
Cora is a surface-associated copper-binding protein important in methylomicrobium album BG8 copper acquisition
Analyse Cora is a surface-associated copper-binding protein important in… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4BZ4
- Type
- protein
- Length
- 1,203 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Copper-repressible polypeptide
- UniProt
- P71489
- Ligands
- CU1, CA
- Pockets
- 6 · best druggability 0.82
Structure
x-ray diffraction · 3 distinct chains · 3% helix, 45% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C, F | Copper-repressible polypeptide | protein | 199 | 3% helix, 45% strand | P71489 |
| B, E | Copper-repressible polypeptide | protein | 204 | 3% helix, 45% strand | P71489 |
| D | Copper-repressible polypeptide | protein | 198 | 3% helix, 44% strand | P71489 |
Ligands and binding sites
- CU1 · Copper (I) ion · metal · 6 copies · chains A, B, C, D, E, F
- CA · Calcium ion · metal · 6 copies · chains A, B, C, D, E, F
- P6G · Hexaethylene glycol · additive · 11 copies · chains A, C, D, B, E, F
- PG4 · Tetraethylene glycol · additive · 6 copies · chains A, B, C, D, E, F
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
6 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1156 | 0.82 | 0.83 | 108 | P6G |
| 2 | 1077 | 0.82 | 0.83 | 103 | empty |
| 3 | 797 | 0.81 | 0.84 | 64 | P6G |
| 4 | 306 | 0.68 | 0.83 | 33 | empty |
| 5 | 224 | 0.58 | 0.79 | 36 | empty |
Interfaces
11 interfaces between chains.
- D–F · 793 Ų buried · 12 hydrogen bonds · protein-protein
- A–C · 774 Ų buried · 14 hydrogen bonds · protein-protein
- E–F · 765 Ų buried · 15 hydrogen bonds · protein-protein
- B–C · 753 Ų buried · 13 hydrogen bonds · protein-protein
- A–B · 739 Ų buried · 12 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 6 modified (nonstandard).
Compared structures
- 4BZ4 · CorA is a surface-associated copper-binding protein important in Methylomicrobium album… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P71489
- Elsewhere: RCSB PDB 4BZ4 · PDBe 4BZ4 · UniProt P71489
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