Research workbench
Structure of alpha-synuclein in complex with an engineered binding protein
Analyse Structure of alpha-synuclein in complex with an engineered binding protein in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4BXL
- Type
- protein
- Length
- 114 residues
- Chains
- 3
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- AS69; Alpha synuclein
- UniProt
- P37840
- Pockets
- 1 · best druggability 0.35
Structure
solution nmr · 2 distinct chains · 41% helix, 28% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | AS69 | protein | 46 | 61% helix, 9% strand | — |
| C | Alpha synuclein | protein | 22 | 0% helix, 68% strand | P37840 |
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 66 | 0.35 | 0.77 | 18 | empty |
Interfaces
3 interfaces between chains.
- B–C · 665 Ų buried · 10 hydrogen bonds · protein-protein
- A–C · 643 Ų buried · 8 hydrogen bonds · protein-protein
- A–B · 398 Ų buried · 1 hydrogen bond · protein-protein
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 4BXL · Structure of alpha-synuclein in complex with an engineered binding protein · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P37840
- Elsewhere: RCSB PDB 4BXL · PDBe 4BXL · UniProt P37840
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