UniProt P37840
Alpha-synuclein (P37840)
Alpha-synuclein (UniProt P37840): 130 experimental structures on GenesisL1, 9 ligands bound, 165 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- P37840
- Protein
- Alpha-synuclein
- Experimental structures
- 130
- Predicted models
- 0
- Ligands
- 9
- Pockets
- 165 · 27 records with a druggable one
Structures
130 records of P37840 in the MolNFT archive: 130 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1XQ8 | Human micelle-bound alpha-synuclein | solution nmr | A | — | — |
| 1XQ8 | Human micelle-bound alpha-synuclein | solution nmr | A | — | — |
| 2JN5 | Solution Structure of a Dodecapeptide from Alpha-Synuclein Bound with Synphilin-1 | solution nmr | A | — | — |
| 2JN5 | Solution structure of a dodecapeptide from alpha-synuclein bound with synphilin-1 | solution nmr | A | — | — |
| 2KKW | SLAS-micelle bound alpha-synuclein | solution nmr, epr | A | — | — |
| 2KKW | Slas-micelle bound alpha-synuclein | solution nmr; epr | A | — | — |
| 2M55 | NMR structure of the complex of an N-terminally acetylated alpha-synuclein peptide with calmodulin | solution nmr | B | — | — |
| 2M55 | NMR structure of the complex of an N-terminally acetylated alpha- synuclein peptide with calmodulin | solution nmr | B | — | — |
| 2N0A | Atomic-resolution structure of alpha-synuclein fibrils | solid-state nmr | A, B, C, D, E, F, G, H, I, J | — | — |
| 2N0A | Atomic-resolution structure of alpha-synuclein fibrils | solid-state nmr | A, B, C, D, E, F, G, H, I, J | — | — |
| 2X6M | Structure of a single domain camelid antibody fragment in complex with a C-terminal peptide of… | x-ray diffraction | B | — | — |
| 2X6M | Structure of a single domain camelid antibody fragment in complex with a C-terminal peptide of… | x-ray diffraction | B | — | — |
| 3Q25 | Crystal structure of human alpha-synuclein (1-19) fused to maltose binding protein (MBP) | x-ray diffraction | A | — | — |
| 3Q25 | Crystal structure of human alpha-synuclein (1-19) fused to maltose binding protein (mbp) | x-ray diffraction | A | — | — |
| 3Q26 | Cyrstal structure of human alpha-synuclein (10-42) fused to maltose binding protein (MBP) | x-ray diffraction | A | — | — |
| 3Q26 | Cyrstal structure of human alpha-synuclein (10-42) fused to maltose binding protein (mbp) | x-ray diffraction | A | — | — |
| 3Q27 | Cyrstal structure of human alpha-synuclein (32-57) fused to maltose binding protein (MBP) | x-ray diffraction | A | — | — |
| 3Q27 | Cyrstal structure of human alpha-synuclein (32-57) fused to maltose binding protein (mbp) | x-ray diffraction | A | — | — |
| 3Q28 | Cyrstal structure of human alpha-synuclein (58-79) fused to maltose binding protein (MBP) | x-ray diffraction | A | — | — |
| 3Q28 | Cyrstal structure of human alpha-synuclein (58-79) fused to maltose binding protein (mbp) | x-ray diffraction | A | — | — |
| 3Q29 | Cyrstal structure of human alpha-synuclein (1-19) fused to maltose binding protein (MBP) | x-ray diffraction | A, C | — | — |
| 3Q29 | Cyrstal structure of human alpha-synuclein (1-19) fused to maltose binding protein (mbp) | x-ray diffraction | A, C | — | — |
| 4BXL | Structure of alpha-synuclein in complex with an engineered binding protein | solution nmr | C | — | — |
| 4BXL | Structure of alpha-synuclein in complex with an engineered binding protein | solution nmr | C | — | — |
| 4R0U | Tgvtava, an amyloid forming segment from alpha synuclein, residues 72-78 | x-ray diffraction | A | — | — |
| 4R0U | Tgvtava, an amyloid forming segment from alpha synuclein, residues 72- 78 | x-ray diffraction | A | — | — |
| 4R0W | Vvtgvta, an amyloid forming segment from alpha synuclein, residues 70-76 | x-ray diffraction | A | — | — |
| 4R0W | Vvtgvta, an amyloid forming segment from alpha synuclein, residues 70- 76 | x-ray diffraction | A | — | — |
| 4RIK | Amyloid forming segment, AVVTGVTAV, from the NAC domain of Parkinson's disease protein… | x-ray diffraction | A | — | — |
| 4RIK | Amyloid forming segment, avvtgvtav, from the nac domain of PARKINSON'S disease protein… | x-ray diffraction | A | — | — |
| 4RIL | Structure of the amyloid forming segment, GAVVTGVTAVA, from the NAC domain of Parkinson's disease… | electron crystallography | A | — | — |
| 4RIL | Structure of the amyloid forming segment, gavvtgvtava, from the nac domain of PARKINSON'S disease… | electron crystallography | A | — | — |
| 4ZNN | MicroED structure of the segment, GVVHGVTTVA, from the A53T familial mutant of Parkinson's disease… | electron crystallography | A | — | — |
| 4ZNN | Microed structure of the segment, gvvhgvttva, from the A53T familial mutant of PARKINSON'S disease… | electron crystallography | A | — | — |
| 6A6B | Cryo-EM structure of alpha-synuclein fiber | electron microscopy | A, B, C, D, E, F, G, H, I, J, K, L | — | — |
| 6CU7 | Alpha Synuclein fibril formed by full length protein - Rod Polymorph | electron microscopy | E, A, B, C, D, F, G, H, I, J | — | — |
| 6CU7 | Alpha synuclein fibril formed by full length protein - rod polymorph | electron microscopy | E, A, B, C, D, F, G, H, I, J | — | — |
| 6CU8 | Alpha synuclein fibril formed by full length protein - twister polymorph | electron microscopy | E, A, B, C, D, F, G, H, I, J | — | — |
| 6FLT | Structure of alpha-synuclein fibrils | electron microscopy | A, B, C, D, E, F, G, H, I, J | — | — |
| 6H6B | Structure of alpha-synuclein fibrils | electron microscopy | A, B, C, D, E, F, G, H, I, J | — | — |
| 6H6B | Structure of alpha-synuclein fibrils | electron microscopy | A, B, C, D, E, F, G, H, I, J | — | — |
| 6I42 | Structure of the alpha-synuclein PRENAC/CYCLOPHILIN a-complex | x-ray diffraction | B | — | — |
| 6L1T | Cryo-EM structure of phosphorylated TYR39 a-synuclein amyloid fibril | electron microscopy | A, B, C, D, E, F, G, H, I, J | — | — |
| 6L1U | Cryo-EM structure of phosphorylated Tyr39 alpha-synuclein amyloid fibril | electron microscopy | A, B, C, D, E, F, G, H, I, J, K, L, M, N, O | — | — |
| 6L1U | Cryo-EM structure of phosphorylated TYR39 alpha-synuclein amyloid fibril | electron microscopy | A, B, C, D, E, F, G, H, I, J, K, L, M, N, O | — | — |
| 6L4S | Cryo-EM structure of alpha-synuclein fiber mutation type E46K | electron microscopy | A, B, C, D, E, F | — | — |
| 6LRQ | Cryo-EM structure of A53T alpha-synuclein amyloid fibril | electron microscopy | A, B, C, D, E, F | — | — |
| 6LRQ | Cryo-EM structure of A53T alpha-synuclein amyloid fibril | electron microscopy | A, B, C, D, E, F | — | — |
| 6OSJ | Cryo-EM structure of the N-terminally acetylated full length alpha-synuclein fibrils (Ac1-140) | electron microscopy | A, B, C, D, E, F, G, H, I, J | — | 6 (best 0.73) |
| 6OSJ | Cryo-EM structure of the N-terminally acetylated full length alpha- synuclein fibrils (AC1-140) | electron microscopy | A, B, C, D, E, F, G, H, I, J | — | — |
| 6OSL | Cryo-EM structure of the N-terminally acetylated C-terminal alpha- synuclein truncation AC1-122 | electron microscopy | A, B, C, D, E, F, G, H, I, J | — | — |
| 6OSM | Cryo-EM structure of the N-terminally acetylated C-terminal alpha- synuclein truncation AC1-103 | electron microscopy | A, B, C, D, E, F, G, H, I, J | — | — |
| 6PEO | Cryo-EM structure of alpha-synuclein H50Q narrow fibril | electron microscopy | A, B, C, D, E | — | — |
| 6PES | Cryo-EM structure of alpha-synuclein H50Q Wide Fibril | electron microscopy | A, B, C, D, E, W, V, X, Y, Z | — | 6 (best 0.70) |
| 6PES | Cryo-EM structure of alpha-synuclein H50Q wide fibril | electron microscopy | A, B, C, D, E, W, V, X, Y, Z | — | — |
| 6RT0 | Cryo-EM structure of alpha-synuclein fibril polymorph 2A | electron microscopy | A, B, C, D, E, F, G, H, I, J | — | — |
| 6RTB | Cryo-EM structure of alpha-synuclein fibril polymorph 2B | electron microscopy | H, C, I, D, J, E, G, B, F, A | — | — |
| 6SST | Cryo-EM structure of alpha-synuclein fibril polymorph 2B | electron microscopy | A, B, C, D, E, F, G, H, I, J | — | — |
| 6SSX | Cryo-EM structure of alpha-synuclein fibril polymorph 2A | electron microscopy | A, B, C, D, E, F, G, H, I, J | — | — |
| 6UFR | Structure of recombinantly assembled E46K alpha-synuclein fibrils | electron microscopy | A, C, E, G, I, F, J, D, H, B | — | — |
70 records more on the page itself.
Ligands
- 1KI · 2-bromanyl-4-[(~{E})-2-[6-[2-(2-fluoranylethoxy)ethyl-methyl-amino]-5-methyl-1,3-benzothiazol-2-yl]ethenyl]phenol · in 3 records
- TFX · 2-[4-(dimethylamino)phenyl]-3,6-dimethyl-1,3-benzothiazol-3-ium · in 3 records
- COA · Coenzyme A · in 2 records
- ACE · Acetyl group · in 1 record
- CMC · Carboxymethyl coenzyme *A · in 1 record
- IZ8 · 4-azanyl-6-[[4-[4-[(~{E})-(8-azanyl-1-oxidanyl-5,7-disulfo-naphthalen-2-yl)diazenyl]-3-methyl-phenyl]-2-methyl-phenyl]diazenyl]-5-oxidanyl-naphthalene-1,3-disulfonic acid · in 1 record
- IZV · 2-[4-(methylamino)phenyl]-1,3-benzothiazol-6-ol · in 1 record
- V79 · copper;trisodium;18-(2-carboxylatoethyl)-20-(carboxylatomethyl)-12-ethenyl-7-ethyl-3,8,13,17-tetramethyl-17,18-dihydroporphyrin-21,23-diide-2-carboxylate · in 1 record
- Y9W · 2-[(~{E})-4-[6-(methylamino)pyridin-3-yl]but-1-en-3-ynyl]-1,3-benzothiazol-6-ol · in 1 record
Experiment against prediction
- 3Q29 chain A against the predicted model P0AEX9: TM-score 0.97, RMSD 0.50 Å
- 3Q29 chain C against the predicted model P0AEX9: TM-score 0.96, RMSD 0.51 Å
- 3Q28 chain A against the predicted model P0AEX9: TM-score 0.95, RMSD 0.70 Å
- 3Q25 chain A against the predicted model P0AEX9: TM-score 0.94, RMSD 0.81 Å
- 3Q27 chain A against the predicted model P0AEX9: TM-score 0.94, RMSD 1.09 Å
- 3Q26 chain A against the predicted model P0AEX9: TM-score 0.93, RMSD 0.50 Å
Elsewhere
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