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Structure of mlkl

Analyse Structure of mlkl in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4BTF
Type: protein
Length: 413 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Mixed lineage kinase domain-like protein
UniProt: Q9D2Y4
Pockets: 5 · best druggability 0.62

Structure

x-ray diffraction · 1 distinct chain · 53% helix, 12% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Mixed lineage kinase domain-like protein	protein	413	53% helix, 12% strand	Q9D2Y4

Ligands and binding sites

EDO · 1,2-ethanediol · additive · 2 copies · chains A
FMT · Formic acid · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	411	0.62	0.77	41	empty
2	245	0.48	0.74	34	empty
3	122	0.48	0.79	26	empty
4	80	0.37	0.76	14	empty
5	54	0.31	0.76	15	empty

Compared structures

4BTF · Structure of MLKL · the same entry in another collection · chain A against A, TM-score 1.00
Q9D2Y4 · AlphaFold monomer V2.0 prediction for mixed lineage kinase domain- like protein (Q9D2Y4) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9D2Y4
Elsewhere: RCSB PDB 4BTF · PDBe 4BTF · UniProt Q9D2Y4

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