Research workbench
Crystal structure of the N terminal domain of trif (tir- domain-containing adapter-inducing interferon-beta)
Analyse Crystal structure of the N terminal domain of trif (tir- domain-containing… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4BSX
- Type
- protein
- Length
- 576 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Tir domain-containing adapter molecule 1
- UniProt
- Q8IUC6
- Pockets
- 9 · best druggability 0.75
Structure
x-ray diffraction · 2 distinct chains · 64% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Tir domain-containing adapter molecule 1 | protein | 144 | 63% helix, 0% strand | Q8IUC6 |
| B, C, D | Tir domain-containing adapter molecule 1 | protein | 144 | 65% helix, 0% strand | Q8IUC6 |
Pockets
9 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 928 | 0.75 | 0.79 | 85 | empty |
| 2 | 159 | 0.45 | 0.75 | 23 | empty |
| 3 | 165 | 0.45 | 0.75 | 23 | empty |
| 4 | 145 | 0.45 | 0.76 | 22 | empty |
| 5 | 122 | 0.42 | 0.76 | 22 | empty |
Interfaces
5 interfaces between chains.
- B–C · 405 Ų buried · 5 hydrogen bonds · protein-protein
- B–D · 264 Ų buried · 5 hydrogen bonds · protein-protein
- C–D · 193 Ų buried · 2 hydrogen bonds · protein-protein
- A–C · 21 Ų buried · 0 hydrogen bonds · protein-protein
- A–D · 12 Ų buried · 0 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 12 modified (engineered).
Compared structures
- 4BSX · Crystal Structure of the N terminal domain of TRIF (TIR-domain- containing… · the same entry in another collection · chain B against B, TM-score 1.00
- Q8IUC6 · AlphaFold monomer V2.0 prediction for tir domain-containing adapter molecule 1 (Q8IUC6) · a predicted model of the same protein · chain B against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8IUC6
- Elsewhere: RCSB PDB 4BSX · PDBe 4BSX · UniProt Q8IUC6
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