Research workbench
NMR structure of human tdp-43 tandem rrms in complex with ug-rich RNA
Analyse NMR structure of human tdp-43 tandem rrms in complex with ug-rich RNA in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4BS2
- Type
- protein + RNA
- Length
- 186 residues
- Chains
- 2
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Tar DNA-binding protein 43; 5'-R(*GP*UP*GP*UP*GP*AP*AP*UP*GP*AP*AP*UP)-3'
- UniProt
- Q13148
- Pockets
- 2 · best druggability 0.45
Structure
solution nmr · 2 distinct chains · 14% helix, 28% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Tar DNA-binding protein 43 | protein | 174 | 14% helix, 28% strand | Q13148 |
| B | 5'-R(*GP*UP*GP*UP*GP*AP*AP*UP*GP*AP*AP*UP)-3' | rna | 12 | — | — |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 132 | 0.45 | 0.77 | 25 | empty |
| 2 | 72 | 0.34 | 0.76 | 14 | empty |
Interfaces
1 interface between chains.
- A–B · 1458 Ų buried · 31 hydrogen bonds · protein-nucleic
Compared structures
- 4BS2 · NMR structure of human TDP-43 tandem RRMs in complex with UG-rich RNA · the same entry in another collection · chain A against A, TM-score 1.00
- Q13148 · AlphaFold monomer V2.0 prediction for tar DNA-binding protein 43 (Q13148) · a predicted model of the same protein · chain A against A, TM-score 0.47
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q13148
- Elsewhere: RCSB PDB 4BS2 · PDBe 4BS2 · UniProt Q13148
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