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Crystal structure of full-length human suppressor of fused (sufu) mutant lacking a regulatory subdomain (crystal form II)
Analyse Crystal structure of full-length human suppressor of fused (sufu) mutant… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4BLA
- Type
- protein
- Length
- 2,925 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Maltose-binding periplasmic protein, suppressor of fused homolog
- UniProt
- P0AEX9, Q9UMX1
- Pockets
- 20 · best druggability 0.79
Structure
x-ray diffraction · 4 distinct chains · 37% helix, 23% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Maltose-binding periplasmic protein, suppressor of fused homolog | protein | 730 | 37% helix, 23% strand | P0AEX9, Q9UMX1 |
| B | Maltose-binding periplasmic protein, suppressor of fused homolog | protein | 733 | 36% helix, 23% strand | P0AEX9, Q9UMX1 |
| C | Maltose-binding periplasmic protein, suppressor of fused homolog | protein | 724 | 37% helix, 23% strand | P0AEX9, Q9UMX1 |
| D | Maltose-binding periplasmic protein, suppressor of fused homolog | protein | 738 | 36% helix, 22% strand | Q9UMX1 |
Pockets
20 pockets found on a 1 Å grid, 15 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 745 | 0.79 | 0.83 | 90 | empty |
| 2 | 344 | 0.71 | 0.84 | 49 | empty |
| 3 | 252 | 0.70 | 0.85 | 45 | empty |
| 4 | 908 | 0.70 | 0.75 | 77 | empty |
| 5 | 531 | 0.68 | 0.78 | 62 | empty |
Interfaces
5 interfaces between chains.
- B–D · 1451 Ų buried · 6 hydrogen bonds · protein-protein
- A–B · 1307 Ų buried · 13 hydrogen bonds · protein-protein
- C–D · 1245 Ų buried · 12 hydrogen bonds · protein-protein
- A–D · 621 Ų buried · 6 hydrogen bonds · protein-protein
- B–C · 550 Ų buried · 3 hydrogen bonds · protein-protein
Compared structures
- 4BLA · Crystal structure of full-length human Suppressor of fused (SUFU) mutant lacking a… · the same entry in another collection · chain D against D, TM-score 1.00
- Q9UMX1 · AlphaFold monomer V2.0 prediction for suppressor of fused homolog (Q9UMX1) · a predicted model of the same protein · chain B against A, TM-score 0.51
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P0AEX9
- Every structure of UniProt Q9UMX1
- Elsewhere: RCSB PDB 4BLA · PDBe 4BLA · UniProt P0AEX9 · UniProt Q9UMX1
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