Research workbench
Nucleotide-free dynamin 1-like protein (DNM1L, DRP1, DLP1)
Analyse Nucleotide-free dynamin 1-like protein (DNM1L, DRP1, DLP1) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4BEJ
- Type
- protein
- Length
- 2,161 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Dynamin 1-like protein
- EC
- 3.6.5.5
- UniProt
- O00429
- Pockets
- 20 · best druggability 0.77
Structure
x-ray diffraction · 4 distinct chains · 61% helix, 9% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Dynamin 1-like protein (EC 3.6.5.5) | protein | 540 | 62% helix, 10% strand | O00429 |
| B | Dynamin 1-like protein (EC 3.6.5.5) | protein | 547 | 60% helix, 9% strand | O00429 |
| C | Dynamin 1-like protein (EC 3.6.5.5) | protein | 534 | 60% helix, 10% strand | O00429 |
| D | Dynamin 1-like protein (EC 3.6.5.5) | protein | 540 | 63% helix, 9% strand | O00429 |
Pockets
20 pockets found on a 1 Å grid, 13 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 132 | 0.77 | 0.96 | 30 | empty |
| 2 | 361 | 0.68 | 0.81 | 50 | empty |
| 3 | 136 | 0.66 | 0.88 | 24 | empty |
| 4 | 619 | 0.65 | 0.76 | 42 | empty |
| 5 | 362 | 0.65 | 0.79 | 62 | empty |
Interfaces
4 interfaces between chains.
- A–B · 1223 Ų buried · 13 hydrogen bonds · protein-protein
- C–D · 1154 Ų buried · 10 hydrogen bonds · protein-protein
- A–C · 860 Ų buried · 8 hydrogen bonds · protein-protein
- B–C · 703 Ų buried · 10 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O00429
- Elsewhere: RCSB PDB 4BEJ · PDBe 4BEJ · UniProt O00429
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