UniProt O00429
Dynamin-1-like protein (O00429)
Dynamin-1-like protein (UniProt O00429), EC 3.6.5.5: 14 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 35 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- O00429
- Protein
- Dynamin-1-like protein
- EC
- 3.6.5.5
- Experimental structures
- 14
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 35 · 2 records with a druggable one
Structures
15 records of O00429 in the MolNFT archive: 14 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3W6N | Crystal structure of human Dlp1 in complex with GMP-PN.Pi | x-ray diffraction | A, B | — | — |
| 3W6N | Crystal structure of human DLP1 in complex with gmp-PN.PI | x-ray diffraction | A, B | — | — |
| 3W6O | Crystal structure of human Dlp1 in complex with GMP-PCP | x-ray diffraction | A, B | — | — |
| 3W6O | Crystal structure of human DLP1 in complex with gmp-pcp | x-ray diffraction | A, B | — | — |
| 3W6P | Crystal structure of human Dlp1 in complex with GDP.AlF4 | x-ray diffraction | A, B | — | — |
| 3W6P | Crystal structure of human DLP1 in complex with GDP.ALF4 | x-ray diffraction | A, B | — | — |
| 4BEJ | Nucleotide-free Dynamin 1-like protein (DNM1L, DRP1, DLP1) | x-ray diffraction | A, B, C, D | — | — |
| 4BEJ | Nucleotide-free dynamin 1-like protein (DNM1L, DRP1, DLP1) | x-ray diffraction | A, B, C, D | — | — |
| 4H1U | Nucleotide-free human dynamin-1-like protein GTPase-GED fusion | x-ray diffraction | A | — | — |
| 4H1U | Nucleotide-free human dynamin-1-like protein GTPase-ged fusion | x-ray diffraction | A | — | — |
| 4H1V | GMP-PNP bound dynamin-1-like protein GTPase-GED fusion | x-ray diffraction | A | — | — |
| 4H1V | Gmp-pnp bound dynamin-1-like protein GTPase-ged fusion | x-ray diffraction | A | — | — |
| 5WP9 | Structural Basis of Mitochondrial Receptor Binding and Constriction by Dynamin-Related Protein 1 | electron microscopy | A, C, E, G, I, K, M, O | GCP, MG | 20 (best 0.84) |
| 8T1H | Cryo-EM structure of a full-length, native Drp1 dimer | electron microscopy | A, B | — | 15 (best 0.71) |
| O00429 | AlphaFold monomer V2.0 prediction for dynamin-1-like protein (O00429) | predicted | A | — | — |
Ligands
Experiment against prediction
- 4BEJ chain B against the predicted model O00429: TM-score 0.93, RMSD 2.39 Å
- 4BEJ chain B against the predicted model O00429: TM-score 0.93, RMSD 2.39 Å
- 4H1V chain A against the predicted model O00429: TM-score 0.89, RMSD 2.84 Å
- 4H1V chain A against the predicted model O00429: TM-score 0.89, RMSD 2.84 Å
- 4H1U chain A against the predicted model O00429: TM-score 0.88, RMSD 2.89 Å
- 4H1U chain A against the predicted model O00429: TM-score 0.88, RMSD 2.89 Å
- 4BEJ chain A against the predicted model O00429: TM-score 0.88, RMSD 3.18 Å
- 4BEJ chain A against the predicted model O00429: TM-score 0.88, RMSD 3.18 Å
- 4BEJ chain D against the predicted model O00429: TM-score 0.78, RMSD 4.67 Å
- 4BEJ chain D against the predicted model O00429: TM-score 0.78, RMSD 4.67 Å
Elsewhere
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