Research workbench

MIMP_ALPHADIBB_A89NLS

Analyse MIMP_ALPHADIBB_A89NLS in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4BA3
Type: protein
Length: 433 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Importin subunit alpha-2; A89NLS
UniProt: P52293
Pockets: 1 · best druggability 0.48

Structure

x-ray diffraction · 2 distinct chains · 74% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Importin subunit alpha-2	protein	427	75% helix, 0% strand	P52293
B	A89NLS	protein	6	0% helix, 0% strand	—

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	78	0.48	0.82	13	empty

Interfaces

1 interface between chains.

A–B · 597 Å² buried · 14 hydrogen bonds · protein-protein

Compared structures

4BA3 · mImp_alphadIBB_A89NLS · the same entry in another collection · chain A against A, TM-score 1.00
P52293 · AlphaFold monomer V2.0 prediction for importin subunit alpha-1 (P52293) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P52293
Elsewhere: RCSB PDB 4BA3 · PDBe 4BA3 · UniProt P52293

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