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Crystal structure of human filamin B actin binding domain with 1ST filamin repeat

Analyse Crystal structure of human filamin B actin binding domain with 1ST filamin… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4B7L
Type: protein
Length: 658 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Filamin-B
UniProt: O75369
Pockets: 10 · best druggability 0.52

Structure

x-ray diffraction · 2 distinct chains · 41% helix, 13% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Filamin-B	protein	328	41% helix, 13% strand	O75369
B	Filamin-B	protein	330	41% helix, 13% strand	O75369

Pockets

10 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	244	0.52	0.76	24	empty
2	244	0.48	0.74	30	empty
3	126	0.38	0.74	20	empty
4	55	0.36	0.79	15	empty
5	103	0.35	0.74	17	empty

Interfaces

1 interface between chains.

A–B · 500 Å² buried · 5 hydrogen bonds · protein-protein

Compared structures

4B7L · Crystal Structure of Human Filamin B Actin Binding Domain with 1st Filamin Repeat · the same entry in another collection · chain B against B, TM-score 1.00
O75369 · AlphaFold monomer V2.0 prediction for filamin-B (O75369) · a predicted model of the same protein · chain A against A, TM-score 0.74

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O75369
Elsewhere: RCSB PDB 4B7L · PDBe 4B7L · UniProt O75369

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