Research workbench
Bacterial translation initiation factor IF2 (1-363), apo form, double mutant K86L H130A
Analyse Bacterial translation initiation factor IF2 (1-363), apo form, double mutant… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4B43
- Type
- protein
- Length
- 346 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Translation initiation factor if-2
- UniProt
- P48515
- Ligands
- MG, IOD
- Pockets
- 2 · best druggability 0.55
Structure
x-ray diffraction · 1 distinct chain · 35% helix, 27% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Translation initiation factor if-2 | protein | 346 | 35% helix, 27% strand | P48515 |
Ligands and binding sites
- MG · Magnesium ion · metal · chains A
- IOD · Iodide ion · ion · 7 copies · chains A
- GOL · Glycerol · additive · 4 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 161 | 0.55 | 0.80 | 26 | empty |
| 2 | 59 | 0.35 | 0.78 | 18 | GOL |
Compared structures
- 4B43 · Bacterial translation initiation factor IF2 (1-363), apo form, double mutant K86L H130A · the same entry in another collection · chain A against A, TM-score 1.00
- P48515 · AlphaFold monomer V2.0 prediction for translation initiation factor if-2 (P48515) · a predicted model of the same protein · chain A against A, TM-score 0.75
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P48515
- Elsewhere: RCSB PDB 4B43 · PDBe 4B43 · UniProt P48515
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