Research workbench
Structure of the px domain from P40PHOX bound to phosphatidylinositol 3-phosphate
Analyse Structure of the px domain from P40PHOX bound to phosphatidylinositol… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1H6H
- Type
- protein
- Length
- 143 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Neutrophil cytosol factor 4
- UniProt
- Q15080
- Ligands
- PIB
- Pockets
- 1 · best druggability 0.54
Structure
x-ray diffraction · 1 distinct chain · 45% helix, 20% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Neutrophil cytosol factor 4 | protein | 143 | 45% helix, 20% strand | Q15080 |
Ligands and binding sites
- PIB · 2-(butanoyloxy)-1-{[(hydroxy{[2,3,4,6-tetrahydroxy-5-(phosphonooxy)cyclohexyl]oxy}phosphoryl) oxy]methyl}ethyl butanoate · ligand · chains A
- GOL · Glycerol · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 177 | 0.54 | 0.79 | 18 | PIB |
Compared structures
- 1H6H · Structure of the PX domain from p40phox bound to phosphatidylinositol 3-phosphate · the same entry in another collection · chain A against A, TM-score 1.00
- Q15080 · AlphaFold monomer V2.0 prediction for neutrophil cytosol factor 4 (Q15080) · a predicted model of the same protein · chain A against A, TM-score 0.94
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q15080
- Elsewhere: RCSB PDB 1H6H · PDBe 1H6H · UniProt Q15080
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.