Research workbench
Crystal structure of human angiogenin with an engineered loop exhibits conformational flexibility at the functional regions of the molecule
Analyse Crystal structure of human angiogenin with an engineered loop exhibits… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4B36
- Type
- protein
- Length
- 228 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Angiogenin, eosinophil cationic-related protein
- EC
- 3.1.27.-
- UniProt
- P03950, Q12762
- Ligands
- CL
- Pockets
- 2 · best druggability 0.44
Structure
x-ray diffraction · 2 distinct chains · 28% helix, 32% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Angiogenin, eosinophil cationic-related protein (EC 3.1.27.-) | protein | 116 | 28% helix, 31% strand | P03950, Q12762 |
| B | Angiogenin, eosinophil cationic-related protein (EC 3.1.27.-) | protein | 112 | 28% helix, 34% strand | P03950, Q12762 |
Ligands and binding sites
- CL · Chloride ion · ion · 2 copies · chains B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 165 | 0.44 | 0.75 | 26 | empty |
| 2 | 96 | 0.37 | 0.75 | 14 | empty |
Interfaces
1 interface between chains.
- A–B · 190 Ų buried · 2 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 6 disulfide (disulfide).
Compared structures
- 4B36 · Crystal Structure of Human Angiogenin with an Engineered Loop Exhibits Conformational… · the same entry in another collection · chain A against A, TM-score 1.00
- P03950 · AlphaFold monomer V2.0 prediction for angiogenin (P03950) · a predicted model of the same protein · chain B against A, TM-score 0.91
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P03950
- Every structure of UniProt Q12762
- Elsewhere: RCSB PDB 4B36 · PDBe 4B36 · UniProt P03950 · UniProt Q12762
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