Research workbench
Structure of a complex between ccps 6 and 7 of human complement factor H and neisseria meningitidis fhbp variant 3 P106A mutant
Analyse Structure of a complex between ccps 6 and 7 of human complement factor H and… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4AYM
- Type
- protein
- Length
- 949 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Complement factor H; Factor H binding protein
- UniProt
- P08603, Q19KF7
- Pockets
- 6 · best druggability 0.75
Structure
x-ray diffraction · 4 distinct chains · 6% helix, 52% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, E, F | Complement factor H | protein | 119 | 8% helix, 35% strand | P08603 |
| B | Complement factor H | protein | 118 | 8% helix, 36% strand | P08603 |
| C | Factor H binding protein | protein | 234 | 4% helix, 61% strand | Q19KF7 |
| D | Factor H binding protein | protein | 240 | 6% helix, 60% strand | Q19KF7 |
Pockets
6 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 936 | 0.75 | 0.78 | 95 | empty |
| 2 | 319 | 0.64 | 0.80 | 48 | empty |
| 3 | 317 | 0.61 | 0.78 | 40 | empty |
| 4 | 214 | 0.52 | 0.77 | 37 | empty |
| 5 | 119 | 0.39 | 0.75 | 23 | empty |
Interfaces
9 interfaces between chains.
- A–D · 1702 Ų buried · 27 hydrogen bonds · protein-protein
- B–C · 1641 Ų buried · 23 hydrogen bonds · protein-protein
- C–E · 415 Ų buried · 3 hydrogen bonds · protein-protein
- A–C · 342 Ų buried · 5 hydrogen bonds · protein-protein
- D–F · 307 Ų buried · 6 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 16 disulfide (disulfide).
Compared structures
- 4AYM · Structure of a complex between CCPs 6 and 7 of Human Complement Factor H and Neisseria… · the same entry in another collection · chain F against F, TM-score 1.00
- P08603 · AlphaFold monomer V2.0 prediction for complement factor H (P08603) · a predicted model of the same protein · chain F against A, TM-score 0.71
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P08603
- Every structure of UniProt Q19KF7
- Elsewhere: RCSB PDB 4AYM · PDBe 4AYM · UniProt P08603 · UniProt Q19KF7
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