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Crystal structure of apo trkb kinase domain

Analyse Crystal structure of apo trkb kinase domain in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4ASZ
Type: protein
Length: 289 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: BDNF/NT-3 growth factors receptor
EC: 2.7.10.1
UniProt: Q16620
Pockets: 3 · best druggability 0.64

Structure

x-ray diffraction · 1 distinct chain · 44% helix, 17% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	BDNF/NT-3 growth factors receptor (EC 2.7.10.1)	protein	289	44% helix, 17% strand	Q16620

Pockets

3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	343	0.64	0.79	36	empty
2	166	0.57	0.81	24	empty
3	64	0.33	0.76	18	empty

Compared structures

4ASZ · Crystal structure of apo TrkB kinase domain · the same entry in another collection · chain A against A, TM-score 1.00
Q16620 · AlphaFold monomer V2.0 prediction for BDNF/NT-3 growth factors receptor (Q16620) · a predicted model of the same protein · chain A against A, TM-score 0.92

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q16620
Elsewhere: RCSB PDB 4ASZ · PDBe 4ASZ · UniProt Q16620

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