UniProt Q16620
BDNF/NT-3 growth factors receptor (Q16620)
BDNF/NT-3 growth factors receptor (UniProt Q16620): 16 experimental structures and 1 predicted model on GenesisL1, 13 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q16620
- Protein
- BDNF/NT-3 growth factors receptor
- Experimental structures
- 16
- Predicted models
- 1
- Pockets
- 13 · 1 record with a druggable one
Structures
17 records of Q16620 in the MolNFT archive: 16 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1HCF | Crystal structure of TrkB-d5 bound to neurotrophin-4/5 | x-ray diffraction | X, Y | — | — |
| 1HCF | Crystal structure of trkb-D5 bound to neurotrophin-4/5 | x-ray diffraction | X, Y | — | — |
| 1WWB | Ligand binding domain of human trkb receptor | x-ray diffraction | X | — | — |
| 1WWB | Ligand binding domain of human trkb receptor | x-ray diffraction | X | — | — |
| 2MFQ | NMR solution structures of FRS2a PTB domain with neurotrophin receptor TrkB | solution nmr | B | — | — |
| 2MFQ | NMR solution structures of FRS2A ptb domain with neurotrophin receptor trkb | solution nmr | B | — | — |
| 4ASZ | Crystal structure of apo TrkB kinase domain | x-ray diffraction | A | — | — |
| 4ASZ | Crystal structure of apo trkb kinase domain | x-ray diffraction | A | — | — |
| 4AT3 | Crystal structure of trkb kinase domain in complex with CPD5N | x-ray diffraction | A | — | — |
| 4AT3 | Crystal structure of trkb kinase domain in complex with CPD5N | x-ray diffraction | A | — | — |
| 4AT4 | Crystal structure of trkb kinase domain in complex with EX429 | x-ray diffraction | A | — | — |
| 4AT4 | Crystal structure of trkb kinase domain in complex with EX429 | x-ray diffraction | A | — | — |
| 4AT5 | Crystal structure of trkb kinase domain in complex with GW2580 | x-ray diffraction | A | — | — |
| 4AT5 | Crystal structure of trkb kinase domain in complex with GW2580 | x-ray diffraction | A | — | — |
| 5MO9 | Structure of human TrkB receptor ligand binding domain in complex with the Fab frgment of antibody… | x-ray diffraction | X | — | — |
| 5MO9 | Structure of human trkb receptor ligand binding domain in complex with the Fab frgment of antibody… | x-ray diffraction | X | — | — |
| Q16620 | AlphaFold monomer V2.0 prediction for BDNF/NT-3 growth factors receptor (Q16620) | predicted | A | — | 13 (best 0.68) |
Experiment against prediction
- 1HCF chain X against the predicted model Q16620: TM-score 0.98, RMSD 0.48 Å
- 1HCF chain X against the predicted model Q16620: TM-score 0.98, RMSD 0.48 Å
- 4AT3 chain A against the predicted model Q16620: TM-score 0.93, RMSD 2.10 Å
- 4AT3 chain A against the predicted model Q16620: TM-score 0.93, RMSD 2.10 Å
- 4ASZ chain A against the predicted model Q16620: TM-score 0.92, RMSD 2.00 Å
- 4ASZ chain A against the predicted model Q16620: TM-score 0.92, RMSD 2.00 Å
- 4AT4 chain A against the predicted model Q16620: TM-score 0.92, RMSD 2.09 Å
- 4AT4 chain A against the predicted model Q16620: TM-score 0.92, RMSD 2.09 Å
- 4AT5 chain A against the predicted model Q16620: TM-score 0.91, RMSD 2.17 Å
- 4AT5 chain A against the predicted model Q16620: TM-score 0.91, RMSD 2.17 Å
Elsewhere
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